US Patent:
20060270862, Nov 30, 2006
Inventors:
Dennis Curran - Pittsburgh PA, US
Youseung Shin - Pittsburgh PA, US
Billy Day - Pittsburgh PA, US
Raghavan Balachandran - Wexford PA, US
Charitha Madiraju - Pittsburgh PA, US
Tiffany Turner - Pittsburgh PA, US
International Classification:
C07D 313/02
C07C 69/73
C07F 9/28
C07F 7/02
US Classification:
549266000, 549216000, 549214000, 560183000
Abstract:
A compound of the following structure: wherein Ris H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; Ris H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiRRR, CHOR, or COR; R, Rand Rare independently an alkyl group or an aryl group; Ris an alkyl group, an aryl group, an alkoxylalkyl group, —RSiRRRor a benzyl group, wherein Ris an alkylene group; Ris an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NRR, wherein Rand Rare independently H, an alkyl group or an aryl group; Ris (CH)where n is and integer in the range of 0 to 5, —CHCH(CH)—, —CH═CH—, —CH═C(CH)—, or —C≡C—; Ris (CH)where p is an integer in the range of 4 to 12, —(CHR)(CHR)(CHR)(CHR)(CHR)C(R)═C(R)C(R)═C(R)—, —(CHR)(CHR)(CHR)(CHR)(CHR)CH(R)CH(R)C(R)═C(R)—, —(CHR)(CHR)(CHR)(CHR)(CHR)C(R)═C(R)CH(R)CH(R)—, —(CHR)(CHR)(CHR)(CHR)(CHR)CH(R)CH(R)CH(R)CH(R)—, wherein y1 and y2 are 1 and y3, y4 and y5 are independently 0 or 1, R, R, R, Rand Rare independently H, CH, or OR, and R, R, R, and Rare independently H or CH, wherein Ris H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiRRR, CHOR, or COR; and Ris H or OR, wherein Ris H, an alkyl group, an aryl group, an aryl group, a benzyl group, a trityl group, —SiRRR, CHOR, or COR; provided that the compound is not dictyostatin 1.
