Inventors:
- South San Francisco CA, US
Jeanmarie GUENOT - San Francisco CA, US
Holger WESCHE - San Francisco CA, US
Robert B. DUBRIDGE - Belmont CA, US
Bryan D. LEMON - Mountain View CA, US
Richard J. AUSTIN - San Francisco CA, US
Pui SETO - San Carlos CA, US
International Classification:
C07K 16/30
C07K 16/28
A61P 35/00
C07K 16/18
Abstract:
Provided herein are prostate specific membrane antigen (PSMA) targeting trispecific proteins comprising a domain binding to CD3, a half-life extension domain, and a domain binding to PSMA. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such PSMA targeting trispecific proteins. Also disclosed are methods of using the disclosed PSMA targeting trispecific proteins in the prevention, and/or treatment diseases, conditions and disorders.