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Philippe V Nantermet

from Lansdale, PA
Age ~59
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Also known as:
Philippe G Nantermet, Philipe Nantermet
Phone and address:
1004 Woodside Cir, Lansdale, PA 19446
(215) 378-3351
Related to:
Heather H Morrison, 62Margaret R Callanan, 33
Connected to:
Lindsay M Nantista, 41Troy D Nantke, 56Andrew R Nantkes, 73Phyliss J Nantkes, 88Gladys M Nanton, 61Ivor A Nanton, 50Seon Nanton, 58Sheryl A Nantus, 60Darren L Nantz, 60Jackie Nantz, 61

Philippe Nantermet Phones & Addresses

  • 1004 Woodside Cir, Lansdale, PA 19446 (215) 378-3351 (215) 412-2735
  • Maplewood, NJ
  • La Jolla, CA
  • San Diego, CA
  • Chapel Hill, NC

Work

Company: Merck Aug 2010 Position: Principal scientist and director

Education

Degree: Doctorates, Doctor of Philosophy School / High School: University of North Carolina at Chapel Hill 1988 to 1993 Specialities: Philosophy, Chemistry

Skills

Drug Discovery • Biotechnology • Pharmaceutical Industry • Drug Development • Medicinal Chemistry • Pharmacology • Lifesciences • Hplc

Languages

French

Industries

Pharmaceuticals

Resumes

Resumes

Philippe Nantermet Photo 1

Principal Scientist And Director

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Location:
Lansdale, PA
Industry:
Pharmaceuticals
Work:
Merck
Principal Scientist and Director
Merck Jan 1999 - Jan 2010
Senior Research Fellow
Novartis Aug 1994 - Aug 1997
Research Scientist
Education:
University of North Carolina at Chapel Hill 1988 - 1993
Doctorates, Doctor of Philosophy, Philosophy, Chemistry
Skills:
Drug Discovery
Biotechnology
Pharmaceutical Industry
Drug Development
Medicinal Chemistry
Pharmacology
Lifesciences
Hplc
Languages:
French

Publications

Wikipedia

UserHansrstolaf/Sandbox/Nicolaou

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Retrosynthetic and synthetic studies K. C. Nicolaou, P. G. Nantermet, ... Christopher F. Claiborne, Philippe G. Nantermet, Elias A. Couladouros, ...

Us Patents

Alpha 1A Adrenergic Receptor Antagonists

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US Patent:
6339090, Jan 15, 2002
Filed:
Jul 29, 1999
Appl. No.:
09/363631
Inventors:
James C. Barrow - Harleysville PA
Harold G. Selnick - Ambler PA
Philippe G. Nantermet - Lansdale PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A01N 4354
US Classification:
514274, 544316
Abstract:
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.

Thrombin Receptor Antagonists

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US Patent:
6403612, Jun 11, 2002
Filed:
Jan 30, 2001
Appl. No.:
09/772352
Inventors:
Philippe G. Nantermet - Lansdale PA
James C. Barrow - Harleysville PA
Harold G. Selnick - Ambler PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 3154
US Classification:
514317, 514327, 514330, 514369, 514375, 514376, 514422, 546192, 546226, 548188, 548200, 548215, 548230, 548517, 548538
Abstract:
A thrombin receptor antagonist having the formula or a pharmaceutically acceptable salt thereof, useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non-toxic amount of such compound to a mammal, preferably a human.

Thrombin Inhibitors

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US Patent:
6515011, Feb 4, 2003
Filed:
Dec 18, 2001
Appl. No.:
10/023776
Inventors:
Harold G. Selnick - Ambler PA
James C. Barrow - Harleysville PA
Philippe G. Nantermet - Lansdale PA
Peter D. Williams - Harleysville PA
Kenneth J. Stauffer - Souderton PA
Philip E. Sanderson - Philadelphia PA
Kenneth E. Rittle - Green Lane PA
Matthew M. Morrissette - Pottstown PA
Catherine M. Wiscount - Allentown PA
Lekhanh O. Tran - Norristown PA
Terry A. Lyle - Lederach PA
Donnette D. Staas - Harleysville PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 3140
US Classification:
514423, 548538, 548528, 548518, 546111, 5462791, 514422, 514343, 514290
Abstract:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e. g. where R is âCH NH , âCH CH NH , or âCH NHC(O)OC(CH ).

Thrombin Receptor Antagonists

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US Patent:
6515023, Feb 4, 2003
Filed:
Jan 30, 2001
Appl. No.:
09/772353
Inventors:
James C. Barrow - Harleysville PA
Philippe G. Nantermet - Lansdale PA
Harold G. Selnick - Ambler PA
John H. Hutchinson - Philadelphia PA
Michael J. Breslin - Drexel Hill PA
Kristen L. Glass - Elkins Park PA
Thomas M. Connolly - Lansdale PA
Andrew Stern - Lower Gwynedd PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 3144
US Classification:
514597, 514303, 514350, 514423, 514438, 514552, 546118, 546318, 546323, 548537, 549 77, 558417, 560 27, 564 49, 564 51
Abstract:
A thrombin receptor antagonist having the formula useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non-toxic amount of such compound to a mammal, preferably a human.

Thrombin Receptor Antagonists

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US Patent:
6544982, Apr 8, 2003
Filed:
Oct 27, 2000
Appl. No.:
09/698811
Inventors:
Harold G. Selnick - Ambler PA
Philippe G. Nantermet - Lansdale PA
James C. Barrow - Harleysville PA
Roger M. Freidinger - Lansdale PA
Thomas Connolly - Lansdale PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 3155
US Classification:
5142171, 546209, 548146, 548186, 548245, 548578
Abstract:
A thrombin receptor antagonist having the formula useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non-toxic amount of such compound to a mammal, preferably a human.

Thrombin Inhibitors

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US Patent:
7026324, Apr 11, 2006
Filed:
Feb 5, 2002
Appl. No.:
10/470936
Inventors:
Mary Beth Young - Lansdale PA, US
Philippe G. Nantermet - Lansdale PA, US
Harold G. Selnick - Ambler PA, US
Peter D. Williams - Harleysville PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/4965
C07D 401/00
C07D 403/00
C07D 405/00
C07D 409/00
US Classification:
51425505, 544405, 5462684, 514338, 514339
Abstract:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein R2 is R3 is selected from the group consisting of 1) hydrogen, 2) halogen, 3) C1–4 alkyl, 4) C3–7 cycloalkyl, 5) CF3, 6) OCF3, 7) C1–4 alkoxy, and 8) cyano; and R12 is a 5-membered heteroaryl ring having 2, 3, or 4 heteroatoms, provided that at least 1 heteroatom is N, and at most 1 of the heteroatoms is S, said ring being unsubstituted or substituted, at any one ring atom, with CH3.

Thrombin Inhibitors

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US Patent:
7084134, Aug 1, 2006
Filed:
May 1, 2003
Appl. No.:
10/427435
Inventors:
James C. Barrow - Harleysville PA, US
Philippe G. Nantermet - Lansdale PA, US
Harold G. Selnick - Ambler PA, US
Assignee:
Merk & Co., Inc. - Rahway NJ
International Classification:
A61K 38/00
US Classification:
514100
Abstract:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:.

Thrombin Inhibitors

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US Patent:
7144899, Dec 5, 2006
Filed:
Feb 5, 2002
Appl. No.:
10/467439
Inventors:
Harold G. Selnick - Ambler PA, US
Mary Beth Young - Lansdale PA, US
Philippe G. Nantermet - Lansdale PA, US
James C. Barrow - Harleysville PA, US
Peter D. Williams - Harleysville PA, US
Terry A. Lyle - Lederach PA, US
Donnette D. Staas - Harleysville PA, US
Kenneth J. Stauffer - Souderton PA, US
Philip E. Sanderson - Philadelphia PA, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/4439
C07D 401/12
US Classification:
514340, 514361, 5462687, 5462691, 548127, 548131, 548134
Abstract:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure Formula (I): wherein u is CH or N; Q is 1)—N(R)CH(R)— wherein the nitrogen atom is attached to R, and Rand Rare independently selected from the group consisting of hydrogen, Ccycloalkyl, and Calkyl, or 2) wherein the nitrogen atom is attached to R, and m is 0, 1, or 2.
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Philippe V Nantermet from Lansdale, PA, age ~59 Get Report