Philip Herman Elzer

6635740, Oct 21, 2003

Sep 24, 1999

09/381879

Frederick M. Enright - Baton Rouge LA
Jesse M. Jaynes - Baton Rouge LA
William Hansel - Baton Rouge LA
Kenneth L. Koonce - Baton Rouge LA
Samuel M. McCann - Baton Rouge LA
Wen H. Yu - Baton Rouge LA
Patricia A. Melrose - Baton Rouge LA
Lane D. Foil - Baton Rouge LA
Philip H. Elzer - Baton Rouge LA

Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA

C07K 1400

530324, 530325, 530326, 530327, 514 12, 514 13, 514 14, 514 15

Amphipathic lytic peptides are ideally suited to use in a ligand/cytotoxin combination to specifically inhibit cells that are driven by or are dependent upon a specific ligand interaction; for example, to induce sterility or long-term contraception, or to attack tumor cells, or to selectively lyse virally-infected cells, or to attack lymphocytes responsible for autoimmune diseases. The peptides act directly on cell membranes, and need not be internalized. Administering a combination of gonadotropin-releasing hormone (GnRH) (or a GnRH agonist) and a membrane-active lytic peptide produces long-term contraception or sterilization in animals in vivo. Administering in vivo a combination of a ligand and a membrane-active lytic peptide kills cells with a receptor for the ligand. The compounds are relatively small, and are not antigenic. Lysis of gonadotropes has been observed to be very rapid (on the order of ten minutes.

6680058, Jan 20, 2004

Feb 22, 2000

09/486143

Frederick M. Enright - Baton Rouge LA
Jesse M. Jaynes - Baton Rouge LA
William Hansel - Baton Rouge LA
Patricia A. Melrose - Baton Rouge LA
Philip H. Elzer - Baton Rouge LA

Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA

A61K 3824

42419511, 4241921, 4241841, 514 14, 514841, 514843

Amphipathic lytic peptides are ideally suited to use in a ligand/cytotoxin combination to induce sterility or long-term contraception in mammals. The peptides act directly on cell membranes, and need not be internalized. Administering a combination of gonadotropin-releasing hormone (GnRH) (or a GnRH agonist) and a membrane-active lytic peptide produces long-term contraception or sterilization in mammals in vivo. The compounds are relatively small, and are not antigenic. Lysis of gonadotropes has been observed to be very rapid (on the order of ten minutes. ) The two componentsâthe ligand and the lytic peptideâmay optionally be administered as a fusion peptide, or they may be administered separately, with the ligand administered slightly before the lytic peptide, to activate cells with receptors for the ligand, and thereby make those cells susceptible to lysis by the lytic peptide.

7566777, Jul 28, 2009

Jul 11, 2003

10/617561

Frederick M. Enright - Baton Rouge LA, US
Jesse M. Jaynes - Raleigh NC, US
William Hansel - Baton Rouge LA, US
Kenneth L. Koonce - Baton Rouge LA, US
Samuel M. McCann - Baton Rouge LA, US
Wen H. Yu - Baton Rouge LA, US
Patricia A. Melrose - Baton Rouge LA, US
Lane D. Foil - Baton Rouge LA, US
Philip H. Elzer - Baton Rouge LA, US

Board of Supervisors of Louisana State University and Agricultural and Mechanical College - Baton Rouge LA

C07H 21/04
C07H 21/02
C12P 21/06
C12P 21/04
C12N 15/09

536 234, 435 691, 435 694, 435 697, 536 2351

Amphipathic lytic peptides are ideally suited to use in a ligand/cytotoxin combination to specifically inhibit cells that are driven by or are dependent upon a specific ligand interaction; for example, to induce sterility or long-term contraception, or to attack tumor cells, or to selectively lyse virally-infected cells, or to attack lymphocytes responsible for autoimmune diseases. The peptides act directly on cell membranes, and need not be internalized. Administering a combination of gonadotropin-releasing hormone (GnRH) (or a GnRH agonist) and a membrane-active lytic peptide produces long-term contraception or sterilization in animals in vivo. Administering in vivo a combination of a ligand and a membrane-active lytic peptide kills cells with a receptor for the ligand. The compounds are relatively small, and are not antigenic. Lysis of gonadotropes has been observed to be very rapid (on the order of ten minutes.

8258100, Sep 4, 2012

Jun 19, 2009

12/488353

Frederick M. Enright - Baton Rouge LA, US
Jesse M. Jaynes - Raleigh NC, US
William Hansel - Baton Rouge LA, US
Kenneth L. Koonce - Baton Rouge LA, US
Samuel M. McCann - Baton Rouge LA, US
Wen H. Yu - Baton Rouge LA, US
Patricia A. Melrose - Baton Rouge LA, US
Lane D. Foil - Baton Rouge LA, US
Philip H. Elzer - Baton Rouge LA, US

Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA

A61K 38/00
A61K 38/25

514 193, 514 97, 514 99, 514 101, 514 102, 514 103, 514 111, 514 194, 514 195, 514 213

Amphipathic lytic peptides are ideally suited to use in a ligand/cytotoxin combination to specifically inhibit cells that are driven by or are dependent upon a specific ligand interaction; for example, to induce sterility or long-term contraception, or to attack tumor cells, or to selectively lyse virally-infected cells, or to attack lymphocytes responsible for autoimmune diseases. The peptides act directly on cell membranes, and need not be internalized. Administering a combination of gonadotropin-releasing hormone (GnRH) (or a GnRH agonist) and a membrane-active lytic peptide produces long-term contraception or sterilization in animals in vivo. Administering in vivo a combination of a ligand and a membrane-active lytic peptide kills cells with a receptor for the ligand. The compounds are relatively small, and are not antigenic. Lysis of gonadotropes has been observed to be very rapid (on the order of ten minutes.

7262163, Aug 28, 2007

Apr 14, 2003

10/414342

Mark L. McLaughlin - Baton Rouge LA, US
Thomas S. Yokum - Greensboro NC, US
Frederick M. Enright - Baton Rouge LA, US
Philip H. Elzer - Baton Rouge LA, US
Robert P. Hammer - Baton Rouge LA, US

Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA

A61K 38/03
C07K 4/00

514 2, 514 14, 514 15, 514 16, 514 17, 530326, 530327, 530328, 530329

“Minimalist” antimicrobial peptides are disclosed based on 50 to 80% α,α-dialkylated amino acids. The peptides are short, cationic, amphipathic, and possess a high helix propensity. Polar α,α-dialkylated amino acids are also disclosed. These peptides are easy and inexpensive to synthesize via solid-phase techniques. The peptides exhibit in vitro anti-bacterial properties at concentrations that are not lethal to normal mammalian cells. The peptides exhibit in vivo bioactivity against intracellular pathogens.

6566334, May 20, 2003

Feb 5, 1998

09/019490

Mark L. McLaughlin - Baton Rouge LA
Thomas S. Yokum - Baton Rouge LA
Frederick M. Enright - Baton Rouge LA
Philip H. Elzer - Baton Rouge LA
Robert P. Hammer - Baton Rouge LA

Board of Supervisors of Louisiana State University and Agricultural and Mechanical College - Baton Rouge LA

C07K 706

514 14, 514 15, 514 16, 530326, 530327, 530328, 530329

âMinimalistâ antimicrobial peptides are disclosed based on 50 to 80% ,-dialkylated amino acids. The peptides are short, cationic, amphipathic, and possess a high helix propensity. Polar ,-dialkylated amino acids are also disclosed. These peptides are easy and inexpensive to synthesize via solid-phase techniques. The peptides exhibit in vitro anti-bacterial properties at concentrations that are not lethal to normal mammalian cells. The peptides exhibit in vivo bioactivity against intracellular pathogens.