Resumes
Resumes
Peter Gannett
View pageLocation:
United States
Peter Gannett Phones & Addresses
-
109 Webster Ave, Morgantown, WV 26501
Publications
Us Patents
Functionalized Microcantilever Sensor And Associated Method For Detection Of Targeted Analytes
View pageUS Patent:
20080160638, Jul 3, 2008
Filed:
Dec 21, 2007
Appl. No.:
11/962229
Inventors:
David Lederman - Morgantown WV, US
Daniel Flynn - Morgantown WV, US
Peter Mico Gannett - Morgantown WV, US
Odille Cue Noriega Myers - Morgantown WV, US
Daniel Flynn - Morgantown WV, US
Peter Mico Gannett - Morgantown WV, US
Odille Cue Noriega Myers - Morgantown WV, US
International Classification:
G01N 33/553
B01J 19/00
B05D 1/36
G01N 33/00
B05D 7/24
G03F 7/00
B01J 19/00
B05D 1/36
G01N 33/00
B05D 7/24
G03F 7/00
US Classification:
436525, 422 681, 427402, 427414, 4274191, 427404, 430296, 436 94, 436 86
Abstract:
A microcantilever sensor for targeted analyte detection can generally comprise a microcantilever having a base and a beam, a metallic coating disposed substantially only on a first surface of a distal-most end of the beam, and a receptor compound immobilized to the metallic coating wherein the receptor compound can have substantially exclusive binding interaction with the analyte. The receptor compound can be a thiol-terminated bifunctional compound having a receptor site with specific binding affinity for the analyte, for example, an isolated Fab′ fragment. The metallic coating can be a noble metal and/or a semi-noble metal, such as a bilayer of chromium and gold. The metallic coating can be applied to the microcantilever surface by electron-beam lithography.
Methods And Compositions For Targeting Afap
View pageUS Patent:
20080234232, Sep 25, 2008
Filed:
Mar 20, 2008
Appl. No.:
12/077653
Inventors:
Daniel C. Flynn - Morgantown WV, US
Peter Gannett - Morgantown WV, US
Peter Gannett - Morgantown WV, US
International Classification:
A61K 31/661
A61P 35/00
A61P 35/00
US Classification:
514121
Abstract:
Embodiments of the invention are directed to methods and compositions for inhibiting activation of cSrc by human actin filament associated protein (AFAP). Libraries and methods of screening compositions for inhibitive activity are also provided. Also provided are methods of treating cancer. Cancer may be, for example, but is not limited to ovarian cancer, breast cancer, and gastrointestinal cancer. Also provided are methods of decreasing resistance to chemotherapy.
Peptides And Chemical Compound For Inhibition Of Shp2 Function
View pageUS Patent:
20090042788, Feb 12, 2009
Filed:
Aug 17, 2007
Appl. No.:
11/893643
Inventors:
Yehenew Mekonnen Agazie - Morgantown WV, US
Peter Mico Gannett - Morgantown WV, US
Peter Mico Gannett - Morgantown WV, US
International Classification:
A61K 38/00
A61P 43/00
A61P 43/00
US Classification:
514 12
Abstract:
The present invention relates to the inhibition of the function of SHP2 by both anti-SHP2 peptides and the chemical compound 4-(2-sulfaminoethyl)benzoic acid, SEBA, and SEBA derivatives binding to the phosphotyrosyl phosphatase domain of SHP2 thereby inhibiting the function of SHP2 both in vitro and in vivo. In addition, the inhibition of SHP2 may be useful as a treatment for human disease, and it has been shown that interfering with SHP2 function using the anti-SHP2 peptides and SEBA compounds reverses cell transformation and induces remission of preformed tumors in vivo demonstrating a possible treatment for cancer.
Nanostructured Electrochemical Biosensor With Aptamer As Molecular Recognition Probe
View pageUS Patent:
20080156646, Jul 3, 2008
Filed:
Nov 27, 2007
Appl. No.:
11/986884
Inventors:
Nianqiang Wu - Morgantown WV, US
William Phillip Petros - Morgantown WV, US
Daniel Charles Flynn - Morgantown WV, US
Peter Mico Gannett - Morgantown WV, US
William Phillip Petros - Morgantown WV, US
Daniel Charles Flynn - Morgantown WV, US
Peter Mico Gannett - Morgantown WV, US
International Classification:
C12Q 1/25
US Classification:
204450, 20440314
Abstract:
The present invention details a nanostructured electrochemical biosensor based on aptamer as the molecular recognition probe. The biosensor is comprised of an electrochemical cell that can be plugged into an electric controller. This electrochemical biosensor contains a working electrode made of the micro-/nano-scale gold dot array pattern, on which aptamer is immobilized on the surface of the dot array as the molecular recognition probe. The aptamer is labeled with an electrochemical indicator. Reversible binding of an analyte to the aptamer causes the change in the conformation of aptamer, consequently brings the electrochemical indicator close to the electrode surface. This results in the electron transfer from the electrochemical indicator to the electrode, which can be read as a change in output current or potential. The invented biosensor is a portable point-of-care device that has higher sensitivity, allows the measurement of the analyte more rapidly and requires much less sample volume than is presently available with current methods of detection.