Inventors:
Barbara B. Kahn - Cambridge MA, US
Qin Yang - Brookline MA, US
Tim Graham - Newton Center MA, US
Odile Peroni - Brookline MA, US
Assignee:
Beth Israel Deaconess Medical Center, Inc. - Boston MA
International Classification:
A61K 49/00
C12Q 1/68
G01N 33/53
G01N 33/534
G01N 33/535
G01N 33/536
G01N 33/561
US Classification:
424 92, 435 61, 435 71, 435 78, 435 792, 436501, 436542
Abstract:
Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of diagnosing insulin resistance and related conditions by detecting modulation of RBP4 activity.