Norbert S Mason

6544552, Apr 8, 2003

Jan 11, 2001

09/757426

Robert E. Sparks - Kirkwood MO
Irwin C. Jacobs - Eureka MO
Norbert S. Mason - Clayton MO

Particle and Coating Technologies, Inc. - St. Louis MO

A61K 920

424464, 424441, 424465, 5147723, 514777, 514781, 514951, 514960

A method of producing a fast-dissolving pharmaceutical delivery device of moderate strength. The delivery device is a fully formed tablet composed of readily available sugars, strength polymers and a volatilizable excipient along with an active ingredient and optional flavorings. The tablet as made will disintegrate in an aqueous medium such as saliva in under 15 seconds, making mastication unnecessary or at least requiring only one or two bites on the tablet. Essential to the invention is the easily obtainable particle size ranges of the sugars and the volatilizable excipient which promotes optimum release and tablet strength. The invention also allows for effective taste masking of the active ingredient with standard particle coating techniques.

51005921, Mar 31, 1992

Dec 20, 1990

7/631249

Robert E. Sparks - Kirkwood MO
Norbert Mason - Clayton MO
Michael Center - St. Louis MO

Washington University Technology Associated, Inc. - St. Louis MO

B29B 908
B29B 910

264 7

A method of melt granulation for powdery material is disclosed wherein the powdery material is discharged onto the upper surface of a heated rotary spreader for migration under centrifugal force to the periphery of the spreader accompanying by melting of a portion of the material and enrobing of non-melted particles by the melted material for discharge as enlarged granules from the periphery of the spreader. To improve the quality of the granules produced, the feed material is supplied to the spreader at two separate locations. The first location is the central portion of the spreader to provide the melted material and the second location is adjacent to the periphery of the spreader. The spreader is preferably in the form of a concave bowl or inverted truncated cone or dish. Feed material is supplied to the first location by a screw feeder extending down the side of the dish and at the second location by a rotary vaned distributor located within the dish which radially flings the feed material onto the inclined dish wall.

50193023, May 28, 1991

Mar 12, 1986

6/838828

Robert E. Sparks - Kirkwood MO
Norbert S. Mason - Clayton MO
Michael Center - St. Louis MO

Washington University Technology Associates, Inc. - St. Louis MO

B29B 908
B29B 910

264 8

Method and apparatus for the formation of granules of a larger size or mass of a desired range from a feed stock of smaller particles comprising feeding a meltable powdery material to be granulated, or a non-meltable powdery material with a meltable binder to the surface of a rotating spreader means in the form of a disk or bowl, at least a portion of which has been heated to a temperature above the melting point of the meltable component of the feed material wherein the rate of feeding, the energy input to the spreader means and the rotational speed of the spreader means are controlled so that there is sufficient time for at least a partial melting of the meltable component of the feed material substantially solely by contact with the heated surface of the spreader means, centrifugally spreading the material across the surface of the disk or bowl and dispersing the same from the edge thereof into an atmosphere cooler than the melting temperature to form the granulated product. For certain materials only a part of the powdery feed material is melted forming a liquid film carrying a major portion of substantially unaffected or minimally affected feed material to produce a product comprising individual granules containing a core as the major part of each granule with the original powdery material essentially unchanged maintained in self-sustaining form by a matrix of melted and resolidified particles bonded to each other at their surface.

46222448, Nov 11, 1986

Aug 23, 1984

6/643547

Galen G. Lapka - Belleville IL
Norbert S. Mason - Clayton MO
Curt Thies - Ballwin MO

The Washington University - St. Louis MO

B01J 1302

42721332

Microcapsules particularly those less than 300 microns in size are provided which are adapted for injection by conventional means to afford controlled release of the encapsulated drug material, such as a narcotic antagonist, an antibiotic or the like, over a prolonged period. The microcapsules are characterized by a solid core material of a solid, injectable drug material and a wall material engulfing the core material and composed of a polymer material such as a bioabsorbable polymer material. The microcapsules are made by providing a system containing a mixture of particles of a solid, injectable drug material and a solution of a bioabsorbable polymer material in a solvent in which the drug material is substantially insoluble. The system is treated to induce phase separation of the bioabsorbable polymer material from the solution by the addition to the system of a phase separation agent at a temperature at least as low as -30. degree. C. Phase separation may also be carried out at room temperature, but in either event, isolation of the microcapsules formed during the phase separation should be carried out at a temperature at least as low as -30. degree. C.

41817184, Jan 1, 1980

Feb 13, 1978

5/877504

Norbert S. Mason - Clayton MO
Robert E. Sparks - Kirkwood MO

A61K 31715
A61K 31725
A61K 3306

424180

Aluminum hydrogels which are stabilized at pH below 7 with a polymer containingcarboxyl groups, e. g. , carboxy methyl cellulose or gum arabic. The gels are useful as phosphate binding agents in the treatment of hyperphosphatemia. Such polymers are incorporated during the formation of the aluminum hydrogel, permitting a high yield to be obtained, and preventing colloidal sol formation during exchange with monovalent anions.

42397146, Dec 16, 1980

Nov 15, 1978

5/960745

Robert E. Sparks - Kirkwood MO
Mariam M. Wahab - Columbus OH
Norbert S. Mason - Clayton MO

Washington University - St. Louis MO

B29D 2700

264 455

The pore size distribution of a microporous separation medium, such as a membrane or gel, is modified so as to provide it with a sharp upper cut-off of preselected molecular size. The modification is effected by first filling the pores of the separation medium with a volatile liquid, and then evaporating a controlled amount of the volatile liquid to form voids at the entrances to the pores. A concentrated solution of a cross-linkable or polymerizable pore-blocking agent, such as a protein, enzyme or polymeric material, is then applied to the surface of the separation medium. The pore-blocking agent is a material which is insoluble in the volatile liquid and whose molecular size distribution has a lower limit corresponding to the preselected molecular size, whereby the pore-blocking agent selectively enters only those pores larger than the preselected size and remains in the voids at the entrances to the pores. After removing excess pore-blocking agent solution from the surface of the separation medium, the pore-blocking agent is insolublized by cross-linking or polymerization so as to immobilize it within the voids and thereby obstruct the entrances to all of the pores larger than the preselected size.