Noel Patrick Bouck

6391850, May 21, 2002

Jun 6, 2001

09/875223

Noel P. Bouck - Oak Park IL
David W. Dawson - Chicago IL
Paul R. Gillis - Chicago IL

Northwestern University - Evanston IL

A61K 3816

514 2, 514 21, 424574, 424537, 424571, 434 701, 434 703

The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.

6670333, Dec 30, 2003

Jun 6, 2001

09/875114

Noel P. Bouck - Oak Park IL
David W. Dawson - Chicago IL
Paul R. Gillis - Chicago IL

Northwestern University - Evanston IL

A61K 31711

514 44, 435 691, 4353201, 435455

The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.

7723313, May 25, 2010

Jul 26, 2006

11/494363

Noel P. Bouck - Occidental CA, US
David W. Dawson - Los Angeles CA, US
Paul R. Gillis - San Francisco CA, US
Olga Volpert - Wilmette IL, US
Susan E. Crawford - Burr Ridge IL, US
Veronica M. Stellmach - Chicago IL, US

Northwestern University - Chicago IL

A61K 48/00
C12N 15/85

514 44, 435325, 4353201

The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.

20030216286, Nov 20, 2003

Jan 14, 2003

10/342243

Noel Bouck - Occidental CA, US
David Dawson - Los Angeles CA, US
Paul Gillis - San Francisco CA, US
Olga Volpert - Wilmette IL, US
Susan Crawford - Burr Ridge IL, US
Veronica Stellmach - Chicago IL, US

NORTHWESTERN UNIVERSITY

C12N005/00
A61K038/00

514/002000, 435/377000, 424/198100

The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.

20040003423, Jan 1, 2004

Feb 10, 2003

10/361516

Noel Bouck - Occidental CA, US
Susan Crawford - Burr Ridge IL, US
Veronica Stellmach - Chicago IL, US

Northwestern University - Evanston IL

A01K067/027
A61K049/00

800/018000, 800/003000

The present invention relates to transgenic knockout animal models null for pigment epithelium-derived factor (PEDF). The present invention also provides methods for generating animal disease models and screening methods for identifying biologically active compounds.

20040014664, Jan 22, 2004

Jun 25, 2003

10/603387

Noel Bouck - Occidental CA, US
David Dawson - Los Angeles CA, US
Paul Gillis - San Francisco CA, US
Olga Volpert - Wilmette IL, US
Susan Crawford - Burr Ridge IL, US
Veronica Stellmach - Chicago IL, US

NORTHWESTERN UNIVERSITY

A61K038/18
A61K048/00

514/012000, 514/044000

The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.

20070003943, Jan 4, 2007

Aug 9, 2005

11/200281

Hanhua Huang - San Diego CA, US
Steven Campbell - Chagrin Falls OH, US
Noel Bouck - Occidental CA, US
Olga Volpert - Wilmette IL, US

Northwestern University - Evanston IL

C12Q 1/68
G01N 33/574

435006000, 435007230

The present invention relates generally to biomarkers for cancer. In particular, the present invention provides compositions and methods for inhibiting angiogenesis and regulating tumor growth. The present invention also provides biomarkers for cancer. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications.

51927446, Mar 9, 1993

Jan 12, 1990

7/464369

Noel P. Bouck - Oak Park IL
Peter J. Polverini - Evanston IL
Deborah J. Good - Chicago IL
Farzan Rastinejad - Los Altos CA

Northwestern University - Evanston IL

A61K 3702
C07K 1506
C07K 1514

514 8

A method of inhibiting angiogenesis and preparations for use therein are disclosed. The preparations comprise human thrombospondin in trimer or monomer form or a fragment thereof capable of inhibiting vascularization. The method and preparations are especially applicable to the treatment of solid tumors including skin cancers for controlling tumor neovascularization and thereby arresting tumor enlargement.