US Patent:
20040121399, Jun 24, 2004
Inventors:
Phillip Brock - Sunnyvale CA, US
Richard Dipietro - Campbell CA, US
Nicolette Fender - San Jose CA, US
Robert Miller - San Jose CA, US
Sally Swanson - San Jose CA, US
Gregory Wallraff - Morgan Hill CA, US
Assignee:
International Business Machines Corporation - Armonk NY
International Classification:
G01N033/53
G01N031/00
G01N033/543
Abstract:
A series of photoactivatible surface bound linker molecules, which can be used to fabricate biomolecular arrays, is described. Specifically, a composition which includes a solid substrate; an organic linking group having one terminal end portion bound to the solid substrate and at least one other terminal end portion containing an alcohol or carbonyl functionality; and an acid labile protecting group selected from acetals and ketals bound to the alcohol or carbonyl functionality. A composition which comprises a solid substrate; an organic linking group having one terminal end portion bound to the solid substrate and at least one other terminal end portion containing an aldehyde group is also described. The present invention further provides a composition which includes a solid substrate; and at least one of a photoacid generator or a sensitizer bound to the solid substrate.