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Nicole M Littmann

from Erie, CO
Age ~53
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Also known as:
Nicole M Littman, Nicole L Mackintosh, Nikki M Littmann
Phone and address:
1628 Harris Ct, Erie, CO 80516
(303) 664-5995
Related to:
Greg W Littmann, 70Nicholas A Berger, 46Farzan R Rhemtulla, 50Marc J Littmann, 55Richard P WhiteLisa R Ginsberg, 57Susan E Littmann, 81Neil A Littmann, 54
Connected to:
Abbey R Littman, 37Alan E Littmann, 50Elizabeth A Littman, 73Glen Littman, 68Grant A Littman, 46Lynn B Littman, 58Lynne D Littman, 124Marion E Littman, 111Nikki J Littman, 62Angie K Litton, 63

Nicole Littmann Phones & Addresses

  • 1628 Harris Ct, Erie, CO 80516 (303) 664-5995
  • 1659 Powell St, Erie, CO 80516 (303) 664-5995
  • Sanibel, FL
  • Lee, FL
  • Boulder, CO

Work

Position: Professional/Technical

Resumes

Resumes

Nicole Littmann Photo 1

Senior Outsourcing Specialist

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Location:
1628 Harris Ct, Erie, CO 80516
Industry:
Pharmaceuticals
Work:
Astrazeneca 1998 - 2000
Research Scientist
Array Biopharma Inc. 1998 - 2000
Senior Outsourcing Specialist
Education:
University of Ottawa 1996 - 1998
University of Waterloo 1991 - 1996
Nicole Littmann Photo 2

Nicole Littmann

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Publications

Us Patents

N-Substituted-N-Sulfonylaminocyclopropane Compounds And Pharmaceutical Use Thereof

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US Patent:
20050222146, Oct 6, 2005
Filed:
Dec 15, 2004
Appl. No.:
11/011781
Inventors:
Andrew Fryer - Erie CO, US
Makoto Shiozaki - Osaka, JP
Nicole Littmann - Erie CO, US
Takashi Inaba - Osaka, JP
Steven Andrews - Longmont CO, US
Katsutaka Yasue - Osaka, JP
Ellen Laird - Longmont CO, US
Masahiro Yokota - Osaka, JP
Julia Haas - Boulder CO, US
Hiroto Imai - Osaka, JP
Katsuya Maeda - Osaka, JP
Yuichi Shinozaki - Osaka, JP
Yoshikazu Hori - Osaka, JP
International Classification:
A61K031/5377
A61K031/496
A61K031/381
C07D049/02
C07D413/02
US Classification:
514232200, 514252130, 514445000, 544145000, 549071000, 544379000
Abstract:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1): wherein Ris —W-A—W-A, W is —(CH)—X—(CH)—, wherein Wis —(CH)—X—(CH)—, m, m1, n and n1 are the same or different and each is 0 to 6, X and Xare the same or different and each is a single bond, etc., Ais an optionally substituted Chydrocarbon ring group, etc. and Ais a substituted Chydrocarbon ring group etc.; Ris —(CH)—CO—R, etc., wherein r is to and Ris a Calkoxy group, etc.; Rand Rare the same or different and each is a hydrogen atom, a Calkyl group, etc.; and Ris —CORetc.; Rand Rare the same or different and each is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

Cyclopropane Compounds And Pharmaceutical Use Thereof

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US Patent:
20060199826, Sep 7, 2006
Filed:
Dec 15, 2004
Appl. No.:
11/011773
Inventors:
Takashi Inaba - Osaka, JP
Julia Haas - Boulder CO, US
Makoto Shiozaki - Osaka, JP
Nicole Littmann - Erie CO, US
Katsutaka Yasue - Osaka, JP
Steven Andrews - Longmont CO, US
Atushi Sakai - Osaka, JP
Andrew Fryer - Erie CO, US
Takafumi Matsuo - Osaka, JP
Ellen Laird - Longmont CO, US
Akira Suma - Osaka, JP
Yuichi Shinozaki - Osaka, JP
Yoshikazu Hori - Osaka, JP
Hiroto Imai - Osaka, JP
Tamotsu Negoro - Osaka, JP
International Classification:
A61K 31/496
A61K 31/4436
A61K 31/416
C07D 49/02
US Classification:
514253010, 514342000, 514406000, 544360000, 546280400, 548365700
Abstract:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein Ris —(CH)—X—(CH)-Aetc., wherein m and n are the same or different and each is 0 to 6, Xis a single bond, etc. and Ais a substituted Chydrocarbon ring group, etc.; Rand Rare the same or different and each is a hydrogen atom, —(CH)—X-(CH)-A, etc., wherein p and q are the same or different and each is 0 to 6, Xis a single bond, etc. and Ais an optionally substituted Chydrocarbon ring group, etc.; Ris —COR, etc., wherein Ris a hydrogen atom, etc.; and Rand Rare the same or different and each is a hydrogen atom, —(CH)—X—(CH)—R, etc., wherein m12 and m12 are the same or different and each is 0 to 6, Xis a single bond, etc. and Ris a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

N-Substituted-N-Sulfonylaminocyclopropane Compounds And Pharmaceutical Use Thereof

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US Patent:
20080242656, Oct 2, 2008
Filed:
Jun 19, 2007
Appl. No.:
11/765136
Inventors:
Andrew M. Fryer - Erie CO, US
Makoto Shiozaki - Osaka, JP
Nicole M. Littmann - Erie CO, US
Takashi Inaba - Osaka, JP
Steven W. Andrews - Longmont CO, US
Katsutaka Yasue - Osaka, JP
Ellen R. Laird - Longmont CO, US
Masahiro Yokota - Osaka, JP
Julia Haas - Boulder CO, US
Hiroto Imai - Osaka, JP
Katsuya Maeda - Osaka, JP
Yuichi Shinozaki - Osaka, JP
Yoshikazu Hori - Osaka, JP
International Classification:
A01N 43/00
US Classification:
51421109
Abstract:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1)wherein Ris —W-A-W-A, W is —(CH)—X—(CH)—, wherein Wis —(CH)—X—(CH)—, m, m1, n and n1 are the same or different and each is 0 to 6, X and Xare the same or different and each is a single bond, etc., Ais an optionally substituted Chydrocarbon ring group, etc. and Ais a substituted Chydrocarbon ring group etc.; Ris —(CH)—CO—R, etc., wherein r is 0 to 6 and Ris a Calkoxy group, etc.; Rand Rare the same or different and each is a hydrogen atom, a Calkyl group, etc.; and Ris —COR, etc.; Rand Rare the same or different and each is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

Cyclopropane Compounds And Pharmaceutical Use Thereof

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US Patent:
20080261994, Oct 23, 2008
Filed:
Jan 18, 2008
Appl. No.:
12/016755
Inventors:
Takashi INABA - Osaka, JP
Julia Hass - Boulder CO, US
Makoto Shiozaki - Osaka, JP
Nicole M. Littmann - Erie CO, US
Katsutaka Yasue - Osaka, JP
Steven W. Andrews - Longmont CO, US
Atushi Sakai - Osaka, JP
Andrew M. Fryer - Erie CO, US
Takafumi Matsuo - Osaka, JP
Ellen R. Laird - Longmont CO, US
Akira Suma - Osaka, JP
Yuichi Shinozaki - Osaka, JP
Yoshikazu Hori - Osaka, JP
Hiroto Imai - Osaka, JP
Tamotsu Negoro - Osaka, JP
International Classification:
A61K 31/496
A61K 31/4436
A61K 31/416
C07D 411/00
C07D 217/00
C07D 265/00
C07D 311/00
A61P 19/02
US Classification:
51425301, 514342, 514406, 544360, 5462804, 5483657, 544160
Abstract:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1):wherein Ris —(CH)—X—(CH)-Aetc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and Ais a substituted Chydrocarbon ring group, etc.; Rand Rare the same or different and each is a hydrogen atom, —(CH)—X—(CH)-A, etc., wherein p and q are the same or different and each is 0 to 6, Xis a single bond, etc. and Ais an optionally substituted Chydrocarbon ring group, etc.; Ris —COR, etc., wherein Ris a hydrogen atom, etc.; and Rand Rare the same or different and each is a hydrogen atom, —(CH)—X—(CH)—R, etc., wherein m12 and m12 are the same or different and each is 0 to 6, Xis a single bond, etc. and Ris a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

Cyclopropane Compounds And Pharmaceutical Use Thereof

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US Patent:
20080306258, Dec 11, 2008
Filed:
May 6, 2008
Appl. No.:
12/149683
Inventors:
Takashi Inaba - Osaka, JP
Julia Haas - Boulder CO, US
Makoto Shiozaki - Osaka, JP
Nicole M. Littmann - Erie CO, US
Katsutaka Yasue - Osaka, JP
Steven W. Andrews - Longmont CO, US
Atushi Sakai - Osaka, JP
Andrew M. Fryer - Erie CO, US
Takafumi Matsuo - Osaka, JP
Ellen R. Laird - Longmont CO, US
Akira Suma - Osaka, JP
Yuichi Shinozaki - Osaka, JP
Yoshikazu Hori - Osaka, JP
Hiroto Imai - Osaka, JP
Tamotsu Negoro - Osaka, JP
International Classification:
C07D 243/08
C07D 413/14
US Classification:
540575, 544137
Abstract:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1):wherein Ris —(CH)—X—(CH)-Aetc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and Ais a substituted Chydrocarbon ring group, etc.; Rand Rare the same or different and each is a hydrogen atom, —(CH)—X—(CH)-A, etc., wherein p and q are the same or different and each is 0 to 6, Xis a single bond, etc. and Ais an optionally substituted Chydrocarbon ring group, etc.; Ris —COR, etc., wherein Ris a hydrogen atom, etc.; and Rand Rare the same or different and each is a hydrogen atom, —(CH)—X—(CH)—Retc., wherein m12 and m12 are the same or different and each is 0 to 6, Xis a single bond, etc. and Ris a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.

Cyclopropane Compounds And Pharmaceutical Use Thereof

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US Patent:
20100105894, Apr 29, 2010
Filed:
Jun 9, 2009
Appl. No.:
12/457391
Inventors:
Takashi Inaba - Osaka, JP
Julia Haas - Boulder CO, US
Makoto Shiozaki - Osaka, JP
Nicole M. Littmann - Erie CO, US
Katsutaka Yasue - Osaka, JP
Steven W. Andrews - Longmont CO, US
Atushi Sakai - Osaka, JP
Andrew M. Fryer - Erie CO, US
Takafuml Matsuo - Osaka, JP
Ellen R. Laird - Longmont CO, US
Akira Suma - Osaka, JP
Yuichi Shinozaki - Osaka, JP
Yoshikazu Hori - Osaka, JP
Hiroto Imai - Osaka, JP
Tamotsu Negoro - Osaka, JP
International Classification:
C07D 243/08
C07C 229/02
C07C 307/00
C07D 409/02
C07D 231/10
C07D 401/02
C07D 261/06
C07D 333/34
C07D 241/04
C07D 271/06
C07D 257/04
C07D 295/00
C07D 215/14
C07D 205/04
C07D 413/02
C07D 241/36
C07D 413/14
C07D 223/14
US Classification:
540575, 562426, 564 89, 5462804, 5483657, 544360, 548247, 549 65, 544383, 548131, 548250, 544159, 546174, 546244, 548952, 544146, 544344, 544137, 540586
Abstract:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1):wherein Ris —(CH)—X—(CH)-Aetc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and Ais a substituted Chydrocarbon ring group, etc.; Rand Rare the same or different and each is a hydrogen atom, —(CH)—X—(CH)-A, etc., wherein p and q are the same or different and each is 0 to 6, Xis a single bond, etc. and Ais an optionally substituted Chydrocarbon ring group, etc.; Ris —COR, etc., wherein Ris a hydrogen atom, etc.; and Rand Rare the same or different and each is a hydrogen atom, —(CH)—X—(CH)—R, etc., wherein m12 and m12 are the same or different and each is 0 to 6, Xis a single bond, etc. and Ris a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
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Nicole M Littmann from Erie, CO, age ~53 Get Report