Nicholas J Catsimpoolas

48791148, Nov 7, 1989

Dec 20, 1985

6/811505

Nicholas Catsimpoolas - Newton Centre MA
Ahmad R. Kamarei - Arlington MA
Ann L. Griffith - Newton Centre MA
Robert S. Sinn - New York NY

Angio-Medical Corporation - Avenue of the Americas NY

A61K 3512
A61K 742
A61K 732
A61K 706

424 95

36 Lipid extracts and lipid fractions from mammalian omenta containing mostly lipids are used cosmetically for skin conditions, skin care and cosmetic products which products have skin softening applications without skin irritation, greasiness or mutagenic effect. These materials with and without ganglioside are used for skin conditions such as keratosis, white spots and the like.

43754015, Mar 1, 1983

May 20, 1981

6/265425

Nicholas Catsimpoolas - Newton Center MA

B01D 1302
G01N 2728

204301

An improved electrophoresis system for simple, rapid and reproducible separations of biological materials such as proteins, nucleic acids, cells, bacteria, cell organelles, etc. is described. The system consists of several subsystems including a first dimensional system having a multi-column rotatable carousel with automatic density gradient maker and sample deposition, a unique fraction collector cassette which can serve as a sample applicator for the second dimension electrophoresis and a slab-gel second-dimensional electrophoresis system. The total system operation is integrated by microprocessor control. Flexibility in the system design and operation allows for running in an analytical or preparative mode at the discretion of the system operator.

49218387, May 1, 1990

Jun 16, 1987

7/062962

Nicholas Catsimpoolas - Newton Centre MA
Ann L. Griffith - Newton Centre MA
Robert S. Sinn - New York NY

Trustees of Boston University - Boston MA
Angio-Medical Corp. - New York NY

A61K 3170
A01N 4304
A01N 5700
C07J 0000

514 25

A method for enhancing angiogenesis and/or blood vascular perfusion in mammals by administering a pharmacologically effective amount of specific angiogenically active non-ionic, anionic, cationic and zwitterionic amphiphilic compounds. An angiogenically effective amount of the angiogenically active compound digitonin is in the range of at least 1. 25 microgram to at least 200 microgram of digitonin. The range including enhancement of vascular perfusion is up to 50 mg of digitonin.

49577417, Sep 18, 1990

Aug 2, 1988

7/227533

Ahmad R. Kamarei - Lexington MA
Nicholas Catsimpoolas - Newton Center MA
Robert McCluer - Acton MA
Takashi Mise - Yokohama, JP
Robert S. Sinn - New York NY

Angio-Medical Corp. - New York NY

A61K 3530
A61K 3512
A61K 3170

424551

Lipid material or ganglioside from mammalian sources e. g. bovine and porcine brain or omentum is used to treat peptic ulcers.

47677465, Aug 30, 1988

Dec 4, 1985

6/805206

Nicholas Catsimpoolas - Newton Centre MA
Robert S. Sinn - New York NY

Trustees of Boston University - Boston MA
Angio-Medical Corporation - New York NY

A61K 3170
A61K 31715
A61K 3120

514 25

Omental lipid fractions accelerate wound healing especially as to epithelialization in mammals.

48883247, Dec 19, 1989

Nov 2, 1987

7/116014

Nicholas Catsimpoolas - Newton Centre MA
Robert McCluer - Acton MA
Robert S. Sinn - New York NY
James Evans - Winchester MA

Angio-Medical Corporation - New York NY
Trustees of Boston University - Boston MA

A61K 3170
A61K 31685

514 25

Compositions which contain lipid containing molecules possessing angiogenic activity are disclosed. The lipid containing molecules have been found in mammalian tissue, particularly the omentum, of various animals. Additionally, known lipids, such as gangliosides, are unexpectedly found to possess angiogenic activity. A method for obtaining the omentum-derived lipids, and for use of these and known lipids, are disclosed as well.

50664964, Nov 19, 1991

Aug 3, 1988

7/227739

Sandor Szabo - Brookline MA
Meryl S. A. Rubin - New Rochelle NY
Michael Klibaner - Brookline MA
Ahmad R. Kamarei - Lexington MA
Robert S. Sinn - New York NY
Nicholas Catsimpoolas - Newton Center MA

Angio-Medical Corporation - New York NY
Trustees of Boston University - Boston MA

A61K 3530
A61K 3512

424570

Ganglioside mixtures and/or lipid mixtures e. g. from brain and omentum, are found to be effective to treat peptic ulcers.

47661119, Aug 23, 1988

Mar 23, 1987

7/011819

Nicholas Catsimpoolas - Newton Centre MA

Trustees of Boston University - Boston MA

A61K 3170
A61K 31685

514 25

Plasmin inhibitory substances have been found in mammalian omental extracts. The substances all contain lipid components. In addition, related commercially available lipid containing molecules, such as mono-, di-, and trisialogangliosides are found to possess unexpected plasmin inhibitory properties. This suggests methods of therapy for diseases and conditions where blood clotting and fibrin degradation products, are implicated.