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Niamh X Cawley

from Potomac, MD
Age ~58
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Also known as:
Cawley Niamh
Phone and address:
9206 Farnsworth Dr, Rockville, MD 20854
Related to:
Mindy Li, 35Kay R Ling, 63Ann S Ling, 88Helen M Cawley, 56Brendan Cawley, 28James Ling, 94Gordon J Ling, 60Paul D Ling, 62Clare S Cawley
Connected to:
Darcy E Cawley, 70Darren D Cawley, 36Dermot A Cawley, 54Diane Cawley, 53Erica M Cawley, 47Gillian Cawley, 42Jake B Cawley, 36Jeanette A Cawley, 89Jerry P Cawley, 51Jessie L Cawley, 97

Niamh Cawley Phones & Addresses

  • 9206 Farnsworth Dr, Potomac, MD 20854
  • Rockville, MD
  • 6008 Walton Rd, Bethesda, MD 20817
  • Gaithersburg, MD
  • Basye, VA
  • Silver Spring, MD

Work

Company: National institutes of health Jul 2001 Position: Staff scientist at national institutes of health

Education

Degree: Doctorates, Doctor of Philosophy School / High School: Uniformed Services University of the Health Sciences 1989 to 1995 Specialities: Biochemistry

Skills

Cell Biology • Biochemistry • Qpcr • Cell Culture • Fluorescence Microscopy • Transfection • Molecular Biology • Molecular Cloning • Lifesciences • Tissue Culture • Protein Expression • Dna • Protein Chemistry • Western Blotting • Immunoprecipitation • Pcr • Cell • Immunology • Microscopy • Protein Purification • Immunocytochemistry • Animal Models • Elisa • Rt Pcr • Genetics • Immunohistochemistry • Life Sciences • Purification

Industries

Research

Resumes

Resumes

Niamh Cawley Photo 1

Staff Scientist At National Institutes Of Health

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Location:
10 Center St, Washington Grove, MD 20880
Industry:
Research
Work:
National Institutes of Health
Staff Scientist at National Institutes of Health
Education:
Uniformed Services University of the Health Sciences 1989 - 1995
Doctorates, Doctor of Philosophy, Biochemistry University College Dublin 1985 - 1989
Bachelors, Bachelor of Science, Biochemistry Blackrock College 1979 - 1985
Skills:
Cell Biology
Biochemistry
Qpcr
Cell Culture
Fluorescence Microscopy
Transfection
Molecular Biology
Molecular Cloning
Lifesciences
Tissue Culture
Protein Expression
Dna
Protein Chemistry
Western Blotting
Immunoprecipitation
Pcr
Cell
Immunology
Microscopy
Protein Purification
Immunocytochemistry
Animal Models
Elisa
Rt Pcr
Genetics
Immunohistochemistry
Life Sciences
Purification

Publications

Us Patents

Nucleic Acids Encoding Growth Hormone With A Modified Rsp Sorting Signal

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US Patent:
7888070, Feb 15, 2011
Filed:
Sep 6, 2007
Appl. No.:
11/850947
Inventors:
Yoke Peng Loh - Bethesda MD, US
Niamh Cawley - Bethesda MD, US
Bruce J. Baum - Bethesda MD, US
Christopher R. Snell - Norfolk, GB
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC
International Classification:
C07H 21/04
C12N 5/16
C12N 15/18
C12N 15/63
US Classification:
435 694, 4353201, 435325, 536 2351
Abstract:
The invention provides a nucleic acid molecule encoding a growth hormone (GH) in which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell. The invention also provides a nucleic acid molecule encoding a GH in which the three-dimensional conformation of the RSP sorting signal has been altered such that the GH can be constitutively secreted by the NRSP in a mammalian cell.

Modified Growth Hormone

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US Patent:
20040158046, Aug 12, 2004
Filed:
Nov 14, 2003
Appl. No.:
10/477651
Inventors:
Yoke Loh - Bethesda MD, US
Niamh Cawley - Bethesda MD, US
Bruce Baum - Bethesda MD, US
Christopher Snell - Norfolk, GB
International Classification:
C07K014/61
US Classification:
530/395000
Abstract:
Growth hormone (GH) in which the regulated secretory pathway (RSP) sorting signal has been mutated as well as GH in which the three-dimensional conformation of the RSP sorting signal has been altered, a composition comprising an effective amount of such a GH in an excipient, a nucleic acid molecule encoding GH in which the RSP sorting signal has been mutated such the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell as well as a nucleic acid molecule encoding GH in which the three-dimensional conformation of the RSP sorting signal has been altered such that the GH can be constitutively secreted by the NRSP in a mammalian cell, a vector comprising such a nucleic acid molecule, an isolated host cell comprising such a vector, a method of treating growth hormone deficiency (GHD) and other diseases in a mammal by administering to the mammal the aforementioned composition, nucleic acid or vector or host cells which have been contacted ex vivo with an aforementioned nucleic acid or vector a method of making a GH in which the RSP sorting signal is mutated comprising mutating one or more amino acids in the RSP sorting signal in GH and the GH so produced, a method of making a GH in which the three-dimensional conformation of the RSP sorting signal is altered comprising mutating one or more amino acids outside of the RSP sorting signal in GH is altered and the GH so produced, a method of making a nucleic acid molecule encoding a GH that can be constitutively secreted by the NRSP in a mammalian cell comprising mutating one or more codons encoding amino acids in the RSP sorting signal in a nucleic acid molecule encoding GH and the nucleic acid molecule so produced, and a method of making a nucleic acid molecule encoding a GH that can be constitutively secreted by the NRSP in a mammalian cell comprising mutating one or more condons encoding amino acids outside of the RSP sorting signal in a nucleic acid molecule encoding GH and the nucleic acid molecule so produced.

Modified Growth Hormone

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US Patent:
20110135614, Jun 9, 2011
Filed:
Jan 19, 2011
Appl. No.:
13/009414
Inventors:
Yoke Peng Loh - Bethesda MD, US
Niamh Cawley - Bethesda MD, US
Bruce J. Baum - Bethesda MD, US
Christopher R. Snell - Norfolk, GB
Assignee:
THE UNITED STATES OF AMERICA, REPRESENTED BY, DEPA RTMENT OF HEALTH - BETHESDA MD
International Classification:
A61K 35/12
A61K 48/00
C07K 14/61
C07H 21/00
A61P 5/06
C07H 1/00
C07K 1/107
US Classification:
424 9321, 514 44 R, 530397, 536 2351
Abstract:
The invention provides, a nucleic acid molecule encoding a growth hormone (GH) in which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell. The invention also provides a nucleic acid molecule encoding a GH in which the three-dimensional conformation of the RSP sorting signal has been altered such that the GH can be constitutively secreted by the NRSP in a mammalian cell.

Method For Predicting And Detecting Tumor Metastasis

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US Patent:
20110152355, Jun 23, 2011
Filed:
Jan 14, 2011
Appl. No.:
13/006603
Inventors:
Niamh X. Cawley - Bethesda MD, US
Saravana Radha Krishna Murthy - Rockville MD, US
Terence K. Lee - Hong Kong, CN
Assignee:
Human Services - Bethesda MD
International Classification:
A61K 31/7088
C12Q 1/68
C12Q 1/37
C07H 21/04
US Classification:
514 44 A, 435 614, 435 618, 435 24, 536 231
Abstract:
The invention provides a method of determining the prognosis of cancer in a subject. The method comprises (a) obtaining a sample from the subject, (b) analyzing the sample for the expression level of a carboxypeptidase E (CPE) splice variant, and (c) correlating the expression level in the sample with the prognosis of cancer in the subject. The invention further provides a method of diagnosing cancer, methods of treatment, kits for detecting mRNA expression of a CPE-ΔN, and inhibitors of CPE-ΔN and compositions thereof.

Method For Predicting And Detecting Tumor Metastasis

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US Patent:
20150031744, Jan 29, 2015
Filed:
Jul 22, 2014
Appl. No.:
14/337408
Inventors:
- Bethesda MD, US
Niamh X. Cawley - Bethesda MD, US
Saravana Radha Krishna Murthy - Rockville MD, US
Terence K. Lee - Hong Kong, CN
International Classification:
C12Q 1/68
A61K 45/06
G01N 33/573
C12N 15/113
US Classification:
514 44 A, 435 612, 506 9, 435 76, 536 231
Abstract:
The invention provides a method of determining the prognosis of cancer in a subject. The method comprises (a) obtaining a sample from the subject, (b) analyzing the sample for the expression level of a carboxypeptidase E (CPE) splice variant, and (c) correlating the expression level in the sample with the prognosis of cancer in the subject. The invention further provides a method of diagnosing cancer, methods of treatment, kits for detecting mRNA expression of a CPE-ΔN, and inhibitors of CPE-ΔN and compositions thereof.
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Niamh X Cawley from Potomac, MD, age ~58 Get Report