Inventors:
James Michael Pierce - Athens GA
Mohamed G. Shoreibah - Comer GA
Beverly Adler - Newbury Park CA
Nevis Lee Fregien - Miami FL
Assignee:
University of Georgia Research Foundation, Inc. - Athens GA
Amgen, Inc. - Thousand Oaks CA
International Classification:
C12N 1554
C12N 1574
C12N 1585
Abstract:
The present invention provides substantially purified UDP-N-acetylglucosamine:. alpha. -6-D-mannoside. beta. -1,6-N-acetylglucosaminyl transferase (GlcNAc T-V; EC 2. 4. 1. 155) proteins and antibodies which specifically bind GlcNAc T-V. The present invention also provides polynucleotide sequences and oligonucleotide probes capable of specifically hybridizing to nucleic acid sequences which encode GlcNAc T-V, and cDNA and genomic clones encoding GlcNAc T-V, as well as nucleotide sequences encoding GlcNAc T-V, as specifically exemplified by GlcNAc T-V coding sequences from rat, hamster, mouse and human.