US Patent:
20110224143, Sep 15, 2011
Inventors:
Thomas P. Sakmar - New York NY, US
Santosh T. Menon - Edgewater NJ, US
Neeraj Kapoor - New York NY, US
Ruchi Gupta - New York NY, US
Dan Raleigh - Stony Brook NY, US
Assignee:
The Rockerfeller University - New York NY
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK - Alabany NY
International Classification:
A61K 38/16
C07K 14/47
C12N 9/48
A61P 13/12
C07K 2/00
A61P 43/00
A61P 1/16
US Classification:
514 154, 530350, 530409, 530359, 530395, 530410, 435212, 514 11, 530300
Abstract:
The invention relates to Nucleobindin-1 (NUCB1) protein variants that are capable of disaggregating amyloid fibrils as well as inhibiting the formation of fibrils in the presence of physiological concentrations of calcium. Isolated NUCB1 protein variants, nucleic acids encoding the protein variants, cells comprising the isolated nucleic acids, pharmaceutical compositions and kits comprising the variants, methods of making the variants, and therapeutic uses of the variants are provided.
