US Patent:
20100178305, Jul 15, 2010
Inventors:
Natalya (Natalia) RAPOPORT - Sandy UT, US
Assignee:
UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT
International Classification:
A61K 31/337
A61P 35/00
A61K 9/10
A61K 31/351
A61K 31/7068
A61K 33/24
A61K 31/5513
A61K 31/7048
A61K 31/56
US Classification:
424400, 514449, 514459, 514 49, 424649, 514221, 514 31, 514178, 977788
Abstract:
Described herein are methods of treating a tumor by contacting the tumor with a therapeutic agent encapsulated in a first nanoemulsion and exposing the tumor to a first ultrasonic radiation of less than 300 kHz to the tumor. In some aspects, the tumor can be contacted with a second nanoemulsion. In some aspects, the second emulsion can be injected directly into the tumor via intratumoral injection before exposing the tumor to the first ultrasonic radiation. In some aspects, the tumor is exposed to a second ultrasonic radiation from about 1 to 5 MHz after the first ultrasonic radiation. The methods described herein can be used to treat numerous tumors including, but not limited to, multidrug resistant tumors and inoperable tumors. These tumors may include, but are not limited to, breast cancers, ovarian cancers, pancreatic cancers, or any combination thereof.