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Natalya Y Rapoport

from Sandy, UT
Age ~86

Natalya Rapoport Phones & Addresses

  • 8444 1275, Sandy, UT 84094 (801) 562-1517
  • 8444 1280, Sandy, UT 84094 (801) 562-1517
  • Quincy, MA
  • Salt Lake City, UT
  • 8444 S 1275 E, Sandy, UT 84094 (801) 231-2480

Work

Position: Retired

Business Records

Name / Title
Company / Classification
Phones & Addresses
Natalya Rapoport
Writer
CENTER FOR DOCUMENTARY EXPRESSION AND ART
Professional Organization
243 E 400 S STE 301, Salt Lake City, UT 84111
(801) 355-3903

Publications

Us Patents

Stabilization And Acoustic Activation Of Polymeric Micelles For Drug Delivery

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US Patent:
6649702, Nov 18, 2003
Filed:
Aug 7, 2002
Appl. No.:
09/979481
Inventors:
Natalya Rapoport - Sandy UT
William G. Pitt - Orem UT
Assignee:
University of Utah Research Foundation - Salt Lake City UT
Brigham Young University - Provo UT
International Classification:
C08L 5300
US Classification:
525299, 525280, 525284, 5253273, 523201, 524504, 524505, 424486, 424487, 424489
Abstract:
Methods are disclosed in which a micelle is stabilized against degradation upon dilution. The micelle comprises molecules of a block polymer having a hydrophobic block and a hydrophilic block. The hydrophobic block forms a core of the micelle with corona from the hydrophilic block. The methods for stabilizing the core are (1) by chemically cross-linking, (2) incorporating a hydrophobic oil (vegetable oil) in the core to render it more hydrophobic and stable, and (3) incorporating a cross-linked interpenetrating network of a stimuli-responsive hydrogel into the core. The hydrogel is responsive to any stimuli, but preferably temperature or pH. A substance such as, drugs, can be incorporated into the dense inner core of the micelles. When subjected to ultrasound, the micelles release the substance, and then reversibly revert to a stable dense core and re-encapsulating the substance when the ultrasound is turned off. By pulsing the ultrasound, it is therefore, to controllably release the substance in a pulsed manner corresponding to the ultrasound signal.

Method Of In Vivo Drug Targeting To Solid Tumors Via Acoustically Triggered Drug Delivery In Polymeric Micelles

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US Patent:
20050003008, Jan 6, 2005
Filed:
Nov 24, 2003
Appl. No.:
10/722379
Inventors:
Natalya Rapoport - Sandy UT, US
International Classification:
A61K009/14
US Classification:
424486000
Abstract:
A method for administering a drug to a selected site in a patient includes (a) administering a composition including a micellar drug carrier having a hydrophobic core and an effective amount of the drug disposed in the hydrophobic core; and (b) applying ultrasonic energy to the selected site such that the drug is released from the hydrophobic core to the selected site. Illustrative drug carriers include ABA triblock copolymers, AB diblock copolymers, mixtures of ABA triblock copolymers and AB diblock copolymers, and mixtures of such polymers with PEGylated diacylphospholipids.

Ultrasonic Nanotherapy Of Solid Tumors With Block Copolymers Stabilized Perfluorocarbon Nanodroplets

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US Patent:
20100178305, Jul 15, 2010
Filed:
Dec 7, 2009
Appl. No.:
12/632254
Inventors:
Natalya (Natalia) RAPOPORT - Sandy UT, US
Assignee:
UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT
International Classification:
A61K 31/337
A61P 35/00
A61K 9/10
A61K 31/351
A61K 31/7068
A61K 33/24
A61K 31/5513
A61K 31/7048
A61K 31/56
US Classification:
424400, 514449, 514459, 514 49, 424649, 514221, 514 31, 514178, 977788
Abstract:
Described herein are methods of treating a tumor by contacting the tumor with a therapeutic agent encapsulated in a first nanoemulsion and exposing the tumor to a first ultrasonic radiation of less than 300 kHz to the tumor. In some aspects, the tumor can be contacted with a second nanoemulsion. In some aspects, the second emulsion can be injected directly into the tumor via intratumoral injection before exposing the tumor to the first ultrasonic radiation. In some aspects, the tumor is exposed to a second ultrasonic radiation from about 1 to 5 MHz after the first ultrasonic radiation. The methods described herein can be used to treat numerous tumors including, but not limited to, multidrug resistant tumors and inoperable tumors. These tumors may include, but are not limited to, breast cancers, ovarian cancers, pancreatic cancers, or any combination thereof.

Stable Nanoemulsions For Ultrasound-Mediated Drug Delivery And Imaging

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US Patent:
20110177005, Jul 21, 2011
Filed:
Jan 19, 2011
Appl. No.:
13/008951
Inventors:
Natalya Y. RAPOPORT - Sandy UT, US
Kweon-Ho NAM - Jeju City, KR
Assignee:
UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT
International Classification:
A61K 49/10
A61P 35/00
A61K 31/337
A61K 31/704
US Classification:
424 937, 514449, 514 34
Abstract:
Described herein are nanoemulsions comprising (1) at least one fluoro ether and (2) a block copolymer comprising a hydrophilic block and hydrophobic block, wherein the nanoemulsion comprises a therapeutic agent in the nanoemulsion. The nanoemulsions are stable and are excellent drug delivery devices for ultrasound-mediated, image guided drug delivery. Also described herein are methods for using the nanoemulsions to treat tumors and cancers as well as using them as imaging agents.

Stable Perfluorocarbon Emulsion For Use As An Artificial Oxygen Carrier

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US Patent:
20110306581, Dec 15, 2011
Filed:
Dec 8, 2009
Appl. No.:
13/133126
Inventors:
Natalya Y. Rapoport - Sandy UT, US
Glenn D. Prestwich - Eastsound WA, US
Russell Morris Condie - Salt Lake City UT, US
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
A61K 31/56
A61K 31/02
A61K 31/025
A61P 39/04
A61P 7/00
A61P 7/02
A61P 39/06
A61K 31/357
C12N 5/071
US Classification:
514171, 514450, 514759, 514761, 514747, 435375
Abstract:
Perfluorocarbon emulsions having a high stability and good oxygen release are disclosed and described. These perfluorocarbon emulsions are typically for use as artificial oxygen carriers. The perfluorocarbon emulsions include a disperse phase of a perfluorocarbon and an emulsion stabilizer, and continuous phase. The emulsion stabilizer can primarily include a poly(ethylene oxide) block copolymer. These stabilized perfluorocarbon emulsions can be used in liquid and/or hydrogel phases of perfusion bioreactors or various other culture systems to enhance cell viability in thick tissue constructs, or as blood substitutes, although other applications may also be considered.

Synergistic Compositions For The Prevention Of Polymer Degradation

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US Patent:
52867722, Feb 15, 1994
Filed:
Nov 27, 1992
Appl. No.:
7/982490
Inventors:
Natalya Rapoport - Salt Lake City UT
Assignee:
The University of Utah - Salt Lake City UT
International Classification:
C08K 513
US Classification:
524345
Abstract:
A polyolefin composition is disclosed comprising polyolefin with a synergistic antioxidant composition of a phenolic oxidation inhibitor and synergist capable of reacting with the phenoxyl radicals to form a phenolic group and regenerate the phenolic oxidation inhibitor. In a preferred embodiment of the invention, the synergist also acts as a metal-complexing agent capable of complexing with trace transition-metal-ions contaminants in the polyolefin.

Stable Nanoemulsions Useful In The Treatment Of Cancer

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US Patent:
20140341803, Nov 20, 2014
Filed:
May 14, 2014
Appl. No.:
14/277405
Inventors:
Natalya Rapoport - Sandy UT, US
Assignee:
UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT
International Classification:
A61K 9/107
A61K 47/34
A61K 31/337
A61K 47/08
US Classification:
424 161, 5147721, 514449
Abstract:
Described herein are methods for treating a tumor or cancer in a subject. The methods involve administering to the subject a nanoemulsion comprising (1) at least one perfluoro crown ether and (2) a block copolymer comprising a hydrophilic block and hydrophobic block, wherein the hydrophobic block is poly(d,l)lactic acid, and wherein the nanoemulsion comprises a therapeutic agent encapsulated in the nanoemulsion. The methods do not require the application of ultrasound or other sources of radiation in order to treat a tumor or cancer in the subject.
Natalya Y Rapoport from Sandy, UT, age ~86 Get Report