US Patent:
20100234287, Sep 16, 2010
Inventors:
Masayori Inouye - New Brunswick NJ, US
Nancy Woychik - Morristown NJ, US
Koichi Inoue - East Brunswick NJ, US
Assignee:
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - Somerset NJ
International Classification:
A61K 38/00
C12Q 1/68
C12N 1/20
A61K 38/16
C07K 2/00
C07K 14/00
US Classification:
514 12, 435 6, 4352521, 514 2, 530300, 530350
Abstract:
The invention provides methods for identifying an agent which prevents or partially prevents an antitoxin from forming a complex with its cognate toxin, comprising contacting a potential agent with a labeled substrate in solution, whereby detection of the label indicates presence of an agent that prevents an antitoxin from forming complex with a toxin. The invention also provides agents capable of interfering with formation of a toxin-antitoxin complex. Such agents act as novel, non-conventional antibiotics against human pathogenic bacteria.