US Patent:
20120128758, May 24, 2012
Inventors:
S. Munir Alam - Durham NC, US
Barton F. Haynes - Durham NC, US
Moses D. Sekaran - Durham NC, US
Georgia Tomaras - Durham NC, US
Xiaoying Shen - Durham NC, US
International Classification:
A61K 39/385
A61K 38/21
A61P 31/18
A61K 9/127
US Classification:
424450, 42419611, 424 857, 4241881
Abstract:
The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.