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Mingdi X Yan

from Bedford, MA
Age ~57
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Also known as:
Ming D Yan, Mingd Yan, Mingdi Li, Yan Mingdi
Related to:
Linda Y Lin, 48Hong Li, 37Yan Tieyu, 56Rui Li, 43Wenjing Li, 47
Connected to:
Alan Yan, 50Albert C Yan, 61Amos L Yan, 32Andrew Yan, 61Ang Yan, 71Angie Yan, 34Bingli Yan, 48Byron H Yan, 68Chui Yan, 43Clayton E Yan, 28

Mingdi Yan Phones & Addresses

  • Bedford, MA
  • 743A Massachusetts Ave APT 743-A, Arlington, MA 02476
  • 13282 Boones Ferry Rd, Lake Oswego, OR 97035 (503) 697-9229
  • Lowell, MA
  • Clackamas, OR
  • Eugene, OR
  • Portland, OR
  • Tewksbury, MA

Publications

Us Patents

Polymeric Structures, Particularly Microstructures, And Methods For Making Same

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US Patent:
7405034, Jul 29, 2008
Filed:
Jan 30, 2004
Appl. No.:
10/769423
Inventors:
Mingdi Yan - Lake Oswego OR, US
Michele A. Bartlett - Buxton OR, US
Assignee:
State of Oregon acting by and through the State Board of Higher Education on behalf of Portland State University - Portland OR
International Classification:
G03F 7/00
B05D 3/00
US Classification:
430312, 4302701, 430311, 430313, 427331, 427532, 427558
Abstract:
Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example, microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such “smart wells” because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

Immobilization Of Discrete Molecules

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US Patent:
20080214410, Sep 4, 2008
Filed:
Jul 9, 2007
Appl. No.:
11/775190
Inventors:
Mingdi Yan - Lake Oswego OR, US
Li Liu - Cambridge, GB
John Gann - Portland OR, US
International Classification:
C40B 40/14
C40B 50/16
US Classification:
506 20, 506 31
Abstract:
Embodiments of a method for covalently immobilizing one or more discrete molecules on a substrate and embodiments of substrates having covalently-immobilized discrete molecules are disclosed. Embodiments of the method can include exposing a substrate to a functionalizing reagent to form a functionalized substrate and exposing the functionalized substrate to a solution comprising the molecule to be immobilized. A reaction-energy source then can be used to activate the functionalizing reagent and covalently bond one or more of the molecules to the substrate. All or a substantial portion of the unbonded molecules then can be removed. Controlling the concentration of the functionalizing reagent to which the substrate is exposed allows the density of the bonding sites on the substrate to be reduced so that, after removal of the unbonded molecules, at least one of the bonded molecules remains on the substrate spatially isolated from any other bonded molecules.

Method For Functionalizing Materials And Devices Comprising Such Materials

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US Patent:
20100028559, Feb 4, 2010
Filed:
May 28, 2009
Appl. No.:
12/455269
Inventors:
Mingdi Yan - Lake Oswego OR, US
Olof Ramström - Stockholm, SE
Li-Hong Liu - Portland OR, US
Xin Wang - Portland OR, US
Michael M. Lerner - Corvallis OR, US
International Classification:
B05D 3/06
C08B 37/00
C08F 120/18
C07K 14/00
B05D 3/02
C07K 16/00
US Classification:
427558, 536 551, 5263297, 530400, 427384, 5303911
Abstract:
Devices comprising functionalized materials, and embodiments of a method for making and using such devices, are disclosed. Exemplary devices include ophthalmic devices, nanoparticles, quartz crystal microbalances, microarrays, and nanocomposites. In particular embodiments, device surfaces are modified with monomers and/or polymers, typically carbohydrate monomers and/or polymers. Embodiments of a method for making and using such devices are disclosed. Monomers and/or polymers are covalently bonded to surfaces using functionalized perhalophenylazides. In some embodiments, device surfaces are functionalized with a perhalophenylazide. One or more monomers and/or polymers subsequently are covalently bonded to the device surface using the perhalophenylazide. In other embodiments, monomers and/or polymers are derivatized with a functionalized perhalophenylazide. The derivatized monomers and/or polymers then are covalently bonded to the device surface using the perhalophenylazide. In some embodiments, graphite is functionalized with perhalophenylazide to produce a functionalized graphene sheet. In other embodiments, graphene sheets are covalently attached to functionalized substrates.

Method Of Making And Using Fluorescent-Tagged Nanoparticles And Microarrays

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US Patent:
20130252843, Sep 26, 2013
Filed:
Nov 22, 2011
Appl. No.:
13/988495
Inventors:
Mingdi Yan - Tewksbury MA, US
Xin Wang - Portland OR, US
Assignee:
THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTL - Portland OR
International Classification:
G01N 33/58
US Classification:
506 9, 436 94, 436 86, 506 32
Abstract:
Disclosed embodiments concern differentiating and classifying one or more targets using a perhalophenylazide-derived nanoparticle probe, or multiple such probes. Particular embodiments concern using statistical analysis to produce score plots illustrating the level of differentiation and/or classification. Also disclosed are methods for making perhalophenylazide-derived nanoparticle probes, individually or by using a microarray technique. Particular embodiments concern methods for using the per halophenylazide-derived nanoparticle probes to diagnose, detect, and/or treat a disease. Kits comprising the perhalophenylazide-derived nanoparticle probes are also disclosed.

Chemical Functionalization Of Surfaces

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US Patent:
60225971, Feb 8, 2000
Filed:
Nov 7, 1997
Appl. No.:
8/966058
Inventors:
Mingdi Yan - Clackamas OR
John F. W. Keana - Eugene OR
International Classification:
B05D 306
US Classification:
427558
Abstract:
Methods for covalently modifying surfaces of various substrates are disclosed, along with various substrates having surfaces modified by such methods. Candidate surfaces include various polymeric, siliceous, metallic, allotrophic forms of carbon, and semiconductor surfaces. The surfaces are exposed to a reagent, having molecules each comprising a nitrenogenic group and a functionalizing group, in the presence of energized charged particles such as electrons and ions, photons, or heat, which transform the nitrenogenic reagent to a nitrene intermediate. The nitrene covalently reacts with any of various chemical groups present on the substrate surface, thereby effecting nitrene addition of the functionalizing groups to the substrate surface. The functionalizing groups can then participate in downstream chemistry whereby any of a large variety of functional groups, including biological molecules, can be covalently bonded to the surface, thereby dramatically altering the chemical behavior of the surface. Such functionalizations of the surface can be done in a single reactive step or in multiple reactive steps.

Methods For Functionalizing And Coating Substrates And Devices Made According To The Methods

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US Patent:
58305394, Nov 3, 1998
Filed:
Nov 17, 1995
Appl. No.:
8/565199
Inventors:
Mingdi Yan - Portland OR
John F. W. Keana - Eugene OR
Goran Karapetrov - Milwaukie OR
Christopher J-P Sevrain - Ridgefield WA
Martin N. Wybourne - Eugene OR
Assignee:
The State of Oregon Acting by and through the State Board of Higher
Education on Behalf of the University of Oregon - Eugene OR
International Classification:
B05D 714
B05D 306
B05D 310
US Classification:
427551
Abstract:
Methods for coating substrates are described. The methods comprise coating at least a portion of a substrate with particular coating materials. The coating materials can be crosslinked and coated onto a substrate. Alternatively, the coating materials may be covalently bonded to the substrates. The coating materials might themselves functionalize the substrate, or provide a biocompatible coating on the substrate. The coating materials might also include electrophilic or nucleophilic groups that allow for the subsequent reaction of the coating materials with additional reagents. The present invention also provides coated workpieces, particularly medical workpieces having a surface for contacting tissue or blood. These workpieces comprise a first layer and a second layer. The first layer comprises a molecular tether covalently bonded to the surface.
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Mingdi X Yan from Bedford, MA, age ~57 Get Report