Inventors:
Xiaowu Pang - Rockville MD, US
Andrew I. Dayton - Knoxville MD, US
Mingjie Zhang - Bethesda MD, US
Assignee:
The United states of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 39/12
C12N 7/00
C12N 7/01
C12N 15/86
C12N 15/40
US Classification:
4242051, 4241991, 4242181, 4352351, 4353201, 536 2372
Abstract:
The present invention discloses the construction of dengue virus subgenomic replicons containing large deletions in the structural region (C-preM-E) of the genome, which replicons are useful as vaccines to protect against dengue virus infection.