Milka I Yanachkova

20010012893, Aug 9, 2001

Dec 6, 2000

09/731256

Arnold Glazier - Newton MA, US
Milka Yanachkova - Newton MA, US
Ivan Yanachkov - Newton MA, US

Drug Innovation & Design, Inc.

C07F009/6524

544/244000, 514/081000

Disclosed are novel prodrugs represented by the following structural formula: Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

20090036650, Feb 5, 2009

Mar 24, 2006

11/886875

Julio Herman Cuervo - Arlington MA, US
Milka Yanachkova - Shrewsbury MA, US
Russell C. Petter - Stow MA, US
Thomas F. Durand-Reville - Cambridge MA, US
Jose Carlos Jimenez-Garcia - Brookline MA, US

C07K 1/04
C07K 2/00

530334, 530300

A backbone nitrogen modifying group can prevent aggregation of peptides during peptide synthesis. The modifying group can promote aqueous solubility of the peptides, and be compatible with solid phase peptide synthesis. Methods for making peptides are also described.

61807907, Jan 30, 2001

Dec 10, 1999

9/459178

Arnold Glazier - Newton MA
Milka Yanachkova - Newton MA
Ivan Yanachkov - Newton MA

Drug Innovation and Design, Inc. - Waltham MA

C07F 96512
C07F 96521
C07F 96561

544243

Disclosed are novel prodrugs represented by the following structural formula: ##STR1## Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

62148117, Apr 10, 2001

Feb 28, 2000

9/514552

Arnold Glazier - Newton MA
Milka Yanachkova - Newton MA
Ivan Yanachkov - Newton MA

Drug Innovation & Design, Inc. - Waltham MA

A61K 31675
C07F 965

514 81

Disclosed are novel prodrugs represented by the following structural formula; ##STR1## Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.

60310960, Feb 29, 2000

May 15, 1998

9/080064

Arnold Glazier - Newton MA
Milka Yanachkova - Newton MA
Ivan Yanachkov - Newton MA

Drug Innovation & Design, Inc. - Waltham MA

C07D47318

544244

Disclosed are novel prodrugs represented by the following structural formula: ##STR1## Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.