Resumes
Resumes
Michael Gravestock Phones & Addresses
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19 Raleigh Rd, Holliston, MA 01746 (508) 893-6207
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Cheshire, MA
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Waltham, MA
Publications
Us Patents
Oxazolidinone Derivatives, Process For Their Preparation And Pharmaceutical Compositions Containing Them
View pageUS Patent:
6617339, Sep 9, 2003
Filed:
Dec 5, 2000
Appl. No.:
09/719012
Inventors:
Michael Barry Gravestock - Holliston MA
Assignee:
Syngenta Limited - London
International Classification:
A61K 31443
US Classification:
514340, 5142102, 51425404, 514376, 514278, 514326, 514362, 514249, 514304, 514369, 514323, 5142531, 5142368, 51425204, 544124, 544235, 544238, 544364, 544369, 546 19, 546 22, 546125, 546256, 546209, 5462714, 5462691, 546341, 548110, 548182, 548187, 548135, 548232
Abstract:
Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and pharmaceutical compositions containing them are described.
Heterocyclylaminomethyloxazolidinones As Antibacterials
View pageUS Patent:
6734200, May 11, 2004
Filed:
Apr 5, 2001
Appl. No.:
09/807113
Inventors:
Michael Barry Gravestock - Waltham MA
Assignee:
AstraZeneca AB - Sodertalje
International Classification:
C07C41314
US Classification:
514376, 548229
Abstract:
Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolyzable ester thereof, wherein, for example, HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selected from N, O and S; Q is selected from, for example, Q1 and Q2: R and R are independently hydrogen or fluoro; T is selected from a range of groups, for example, an N-linked (fully unsaturated) 5-membered heteroaryl ring system or a group of formula (TC5): wherein Rc is, for example, R COâ, R SO â or R CSâ; wherein R is, for example, optionally substituted (1-10C)alkyl or R C(O)O(1-6C)alkyl wherein R is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.
Substituted Isoxazolines And Their Use As Antibacterial Agents
View pageUS Patent:
7081538, Jul 25, 2006
Filed:
Nov 28, 2000
Appl. No.:
10/111562
Inventors:
Michael Barry Gravestock - Waltham MA, US
Michael John Betts - Macclesfield, GB
Michael John Betts - Macclesfield, GB
Assignee:
AstraZeneca AB - Södertälje
International Classification:
A61K 31/505
A61K 31/42
C07D 413/06
A61K 31/42
C07D 413/06
US Classification:
548240, 548243, 548244, 548245, 544333, 546209, 5462721, 514256, 514275, 514326, 514340, 514378, 514380
Abstract:
Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, X is O, S or NH; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selected from N, O and S; Q is selected from, for example, Q1 and Q2: Rand Rare independently hydrogen or fluoro; T is selected from a range of groups, for example, an N-linked (fully unsaturated) 5-membered heteroaryl ring system or a group of formula (TC5): wherein Rc is, for example, RCO—, RSO— or RCS—; wherein Ris, for example, optionally substituted (1–10C)alkyl or RC(O)O(1–6C)alkyl wherein Ris optionally substituted (1–10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.
Heterocyclylaminomethyloxazolidinones As Antibacterials
View pageUS Patent:
7087629, Aug 8, 2006
Filed:
Mar 6, 2003
Appl. No.:
10/382396
Inventors:
Michael Barry Gravestock - Waltham MA, US
Assignee:
AstraZeneca AB - Södertälje
International Classification:
A61K 31/422
C07D 413/12
C07D 417/12
C07D 413/12
C07D 417/12
US Classification:
514376, 548229, 548231
Abstract:
Compounds of formula (I).
Oxazolidinone Derivatives With Antibiotic Activity
View pageUS Patent:
7141583, Nov 28, 2006
Filed:
Apr 23, 2001
Appl. No.:
10/258355
Inventors:
Michael Barry Gravestock - Waltham MA, US
Michael John Betts - Macclesfield, GB
Ian Richard Matthews - Haselmere, GB
David Alan Griffin - Haselmere, GB
Michael John Betts - Macclesfield, GB
Ian Richard Matthews - Haselmere, GB
David Alan Griffin - Haselmere, GB
Assignee:
AstraZeneca AB - Södertälje
International Classification:
A61K 31/4439
A61K 31/454
C07D 401/14
A61K 31/454
C07D 401/14
US Classification:
514326, 514340, 546210, 5462714
Abstract:
Compounds of the formula (I), or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof,.
Antibacterial 1,3-Oxazolidin-2-One Derivatives
View pageUS Patent:
7157482, Jan 2, 2007
Filed:
Mar 16, 2004
Appl. No.:
10/550039
Inventors:
Michael Barry Gravestock - Waltham MA, US
Neil James Hale - Macclesfield, GB
Sheila Irene Hauck - Waltham MA, US
Neil James Hale - Macclesfield, GB
Sheila Irene Hauck - Waltham MA, US
Assignee:
AstraZeneca AB - Sodertalje
International Classification:
A01N 43/76
A01N 43/72
A01N 43/828
A01N 43/647
A01N 43/56
C07D 261/06
C07D 263/04
A01N 43/72
A01N 43/828
A01N 43/647
A01N 43/56
C07D 261/06
C07D 263/04
US Classification:
514376, 514359, 514403, 514372, 514378, 514361, 548229, 548255, 548247, 548206, 5483641
Abstract:
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereof, wherein: N—HET is for example triazolyl substituted with R; Ris for example optionally substituted (1-4C)alkyl; Q is for example phenyl or pyridyl, substituted with T; T is for example selected from (TAa1 to TAa12) such as (TAa1 and TAa5); formula (II): R, R, Rare for example selected from hydrogen, (1-4C)alkyl, (1-4C)alkoxycarbonyl, (1-4C)alkanoyl and carbamoyl; processes for making them, compositions containing them and their use as antibacterial agents are described.
Antibacterial Oxalidinones
View pageUS Patent:
7186738, Mar 6, 2007
Filed:
Mar 16, 2004
Appl. No.:
10/550038
Inventors:
Michael Barry Gravestock - Waltham MA, US
Neil James Hale - Macclesfield, GB
Sheila Irene Hauck - Waltham MA, US
Neil James Hale - Macclesfield, GB
Sheila Irene Hauck - Waltham MA, US
Assignee:
AstraZeneca AB - Sodertajle
International Classification:
A01N 43/76
A01N 43/72
A01N 43/828
A01N 43/647
A01N 43/56
C07D 261/06
C07D 263/04
A01N 43/72
A01N 43/828
A01N 43/647
A01N 43/56
C07D 261/06
C07D 263/04
US Classification:
514376, 514359, 514403, 514372, 514378, 514361, 548229, 548255, 548247, 548206, 5483641
Abstract:
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereo Formula (I): wherein N-HeT is for example triazolyl; Q is for example phenyl or pyridyl, substituted with: T is for example selected from (TAa1 to TAa12) such as (TAa1) and (TAa5): R, R, Rare for example selected from hydrogen, (1–4C)alkyl, (1–4C)alkoxy-carbonyl, (1–4C)alkanoyl and carbamoyl; processes for making them, compositions containing them and their use as antibacterial agents are described.
Hydroxymethyl Substituted Dihydroisoxazole Derivatives Useful As Antibiotic Agents
View pageUS Patent:
7192974, Mar 20, 2007
Filed:
Feb 24, 2004
Appl. No.:
10/546373
Inventors:
Michael Barry Gravestock - Waltham MA, US
Daniel Robert Carcanague - Waltham MA, US
Neil James Hales - Macclesfield, GB
Daniel Robert Carcanague - Waltham MA, US
Neil James Hales - Macclesfield, GB
Assignee:
AstraZeneca AB - Sodertajle
International Classification:
C07D 413/14
A61K 31/4427
A61K 31/4427
US Classification:
514340, 5462714
Abstract:
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, (I) R1a is NH(C═W)Ror (a); W is O or S; Rand Rare for example H or F; Ris for example hydrogen, or halogen; Ris selected from hydrogen, (2–6C)alkyl (optionally substituted); Rand Rare independently selected from hydrogen, and (1–4C)alkyl (optionally substituted); wherein Ris either a hydroxymethyl substituent on C-4′ of the isoxazoline ring; or Ris a hydroxymethyl substituent on C-5′ of the isoxazoline ring and the stereochemistry at C-5′ of the isoxazoline ring and at C-5 of the oxazolidinone ring is selected, such that the compound of formula (I) is a single diastereomer; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.