US Patent:
20110086346, Apr 14, 2011
Inventors:
Charronne Florence Davis - Elkins Park PA, US
Mehmet Tevfik Dorak - Pembroke Pines FL, US
Assignee:
Medical Diagnostic Laboratories LLC - Hamilton NJ
International Classification:
C12Q 1/68
G01N 33/00
Abstract:
The present invention is directed to novel haplotype tagging single nucleotide polymorphisms (SNPs) in specific regions outside the HFE gene that serve as a reliable biomarker for a decreased risk for childhood lymphoblastic leukemia (ALL) in a child. There is provided herein methods and reagents for assessing the haplotype tagging SNPs selected from the group consisting of rs807212, rs198853, rs9467664, rs2213284, rs2230655 and rs12346. The method useful in applying these SNPs in predicting a decreased risk of childhood lymphoblastic leukemia (ALL) is also disclosed.