Maurizio Poeta - Charleston SC,
Chiara Luberto - Charleston SC,
Talar Kechichian - Glendale CA,
Methods for the diagnosis and treatment of fungal infections caused by microorganisms producing glucosylceramide are provided. In particular, methods for diagnosing or predicting dissemination of a fungal infection from the lungs to the blood stream of a patient are provided. Methods for treating a fungal infection and/or preventing the dissemination of a fungal infection from the lungs to the blood stream or to other organs of a patient, and methods for preventing or treating a fungal infection in a patient by administering a therapeutically effective amount of a fungal glucosylceramide synthase inhibitor to a patient. Such methods are particularly useful for use with patients at risk to develop fungal infections, such as HIV or cancer patients, patients hospitalized in intensive care units, or patients receiving immunosuppressive drugs such as transplant patients.