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Maurizio Pellecchia

from San Diego, CA
Age ~56
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Also known as:
Maurizio Pellechia, Maurizzio Pellecchia, Mavrizio Pellecchia, Pellecchia Maurizzio
Phone and address:
4253 Karensue Ave, San Diego, CA 92122
Related to:
Trey G Ideker, 52Daniel S Teranes, 50Jane L Teranes, 55Paul S Teranes, 89Richard P Teranes, 56Amy B Teranes, 47Barbara J Teranes, 84
Connected to:
Amy M Pellecchia, 44Brenda Pellecchia, 67Carie A Pellecchia, 60Kathleen A Pellecchia, 74Michele T Pellecchia, 52Claudia E Pellecer, 59Cynthia M Pellechio, 46James R Pellechia, 52John V Pellechia, 61Maria Pellechio, 67

Maurizio Pellecchia Phones & Addresses

  • 4253 Karensue Ave, San Diego, CA 92122
  • 4386 Campus Ave, San Diego, CA 92103 (619) 255-4289
  • 1505 Robinson Ave, San Diego, CA 92103 (619) 255-4289
  • 1501 Robinson Ave, San Diego, CA 92103
  • 7070 Condon Dr, San Diego, CA 92122 (858) 652-0049
  • 8746 Villa La Jolla Dr, La Jolla, CA 92037 (858) 453-5875
  • Ann Arbor, MI
  • Grosse Pointe, MI

Resumes

Resumes

Maurizio Pellecchia Photo 1

Director Center For Molecular And Translational Medicine

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Location:
4845 Tula Ct, San Diego, CA 92122
Industry:
Research
Work:
BIMR since Apr 2002
Professor
Education:
The University of Michigan 1998 - 1999
Università Degli Studi Di Napoli Federico Ii 1992 - 1996
Doctorates, Doctor of Philosophy, Philosophy Eth Zürich 1993 - 1996
Università Degli Studi Di Napoli Federico Ii 1987 - 1992
Master of Science, Masters, Biology, Chemistry University of Michigan
Università Di Napoli "Federico Ii"
Skills:
Biochemistry
Protein Chemistry
Chemistry
Protein Expression
Drug Development
Science
Research
Nmr
Drug Design
Spectroscopy
Organic Chemistry
Lifesciences
Cancer
Molecular Modeling
Lecturing
University Teaching
Medicinal Chemistry
Molecular Biology
Biophysics
Structural Biology
Pharmacology
Life Sciences
Nuclear Magnetic Resonance
Computational Chemistry
Computational Biology
Cell Biology
Biotechnology
Interests:
Exercise
Investing
Electronics
Home Improvement
Reading
Sports
Home Decoration
Languages:
English
Italian
Maurizio Pellecchia Photo 2

Maurizio Pellecchia

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Business Records

Name / Title
Company / Classification
Phones & Addresses
Maurizio Pellecchia
Ancorex Therapeutics, LLC
Pharmaceutical R&D Services
4845 Tula Ct, San Diego, CA 92122

Publications

Us Patents

Nmr-Solve Method For Rapid Identification Of Bi-Ligand Drug Candidates

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US Patent:
6797460, Sep 28, 2004
Filed:
Aug 15, 2001
Appl. No.:
09/930600
Inventors:
Daniel S. Sem - San Diego CA
Maurizio Pellecchia - San Diego CA
Assignee:
Triad Therapeutics, Inc. - San Diego CA
International Classification:
C12Q 100
US Classification:
435 4, 435 15, 435 16, 435 17, 435 25, 435 26
Abstract:
Methods for rapidly identifying drug candidates that can bind to an enzyme at both a common ligand site and a specificity ligand site, resulting in high affinity binding. The bi-ligand drug candidates are screened from a focused combinatorial library where the specific points of variation on a core structure are optimized. The optimal points of variation are identified by which atoms of a ligand bound to the common ligand site are identified to be proximal to the specificity ligand site. As a result, the atoms proximal to the specificity ligand site can then be used as a point for variation to generate a focused combinatorial library of high affinity drug candidates that can bind to both the common ligand site and the specificity ligand site. Different candidates in the library can then have high affinity for many related enzymes sharing a similar common ligand site.

Sea-Trosy And Related Methods

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US Patent:
6979531, Dec 27, 2005
Filed:
Dec 19, 2001
Appl. No.:
10/032140
Inventors:
Daniel S. Sem - San Diego CA, US
Maurizio Pellecchia - San Diego CA, US
Assignee:
Triad Therapeutics, Inc. - San Diego CA
International Classification:
C12Q001/00
US Classification:
435 4, 324307, 324309, 324200, 435 71
Abstract:
A method for preferentially observing an exposed position () of a macromolecule. A sample is obtained having a macromolecule () with a first proton () and a second molecule () with a second proton (); then applying a magnetic field () to the sample and irradiating the sample with a pulse sequence () that preferentially demagnetizes protons of the macromolecule () relative to the second proton (); allowing the second proton () to exchange () with an exposed proton () of the macromolecule; and detecting the magnetization from the relatively magnetized second proton (), which is now bound to the exposed position () of the macromolecule. The invention also provides a method for observing a position in the macromolecule that bind a ligand.

Nmr-Solve Method For Rapid Identification Of Bi-Ligand Drug Candidates

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US Patent:
7252931, Aug 7, 2007
Filed:
Jul 2, 2004
Appl. No.:
10/884181
Inventors:
Daniel S. Sem - San Diego CA, US
Maurizio Pellecchia - San Diego CA, US
Assignee:
Triad Therapeutics, Inc. - San Diego CA
International Classification:
C12Q 1/00
US Classification:
435 4, 435 15, 435 25, 435 26, 435DIG 2, 435DIG 46, 435DIG 47
Abstract:
Methods for rapidly identifying drug candidates that can bind to an enzyme at both a common ligand site and a specificity ligand site, resulting in high affinity binding. The bi-ligand drug candidates are screened from a focused combinatorial library where the specific points of variation on a core structure are optimized. The optimal points of variation are identified by which atoms of a ligand bound to the common ligand site are identified to be proximal to the specificity ligand site. As a result, the atoms proximal to the specificity ligand site can then be used as a point for variation to generate a focused combinatorial library of high affinity drug candidates that can bind to both the common ligand site and the specificity ligand site. Different candidates in the library can then have high affinity for many related enzymes sharing a similar common ligand site.

Nuclear Magnetic Resonance Assembly Of Chemical Entities

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US Patent:
7653490, Jan 26, 2010
Filed:
Jun 13, 2002
Appl. No.:
10/172485
Inventors:
Daniel S. Sem - San Diego CA, US
Maurizio Pellecchia - San Diego CA, US
Qing Dong - San Diego CA, US
Mark Kelly - San Diego CA, US
Min S. Lee - Carlsbad CA, US
Assignee:
Triad Liquidating Company LLC - Rancho Santa Fe CA
International Classification:
G06F 7/00
US Classification:
702 19, 702 20, 703 11, 703 13, 707102, 530350
Abstract:
The invention provides a method for obtaining a binding compound for a protein family, wherein the members of the protein family bind a common ligand. The method includes the steps of (a) providing a sample containing a protein from the protein family, a first ligand and a second ligand under conditions wherein the first ligand, the second ligand and the protein form a bound complex; (b) detecting magnetization transfer between the first ligand and the second ligand in the bound complex, thereby determining that the two ligands are proximal in the bound complex; and (c) obtaining a candidate binding compound including the first ligand, or a fragment thereof linked to the second ligand, or a homolog thereof, whereby the population contains binding compounds that bind to members of the protein family.

Inhibition Of Lethal Factor Protease Activity From Anthrax Toxin

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US Patent:
7718680, May 18, 2010
Filed:
Sep 23, 2005
Appl. No.:
11/233924
Inventors:
Maurizio Pellecchia - San Diego CA, US
Alex Strongin - San Diego CA, US
Assignee:
Burnham Institute for Medical Research - La Jolla CA
International Classification:
A61K 31/426
US Classification:
514369
Abstract:
The present invention provides compounds that efficiently and specifically inhibit lethal factor (LF) protease activity of anthrax toxin.

Use Of Selective Labeling To Detect And Characterize Molecular Interactions By Nuclear Magnetic Resonance Spectroscopy

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US Patent:
7723076, May 25, 2010
Filed:
Aug 14, 2006
Appl. No.:
11/504133
Inventors:
Maurizio Pellecchia - San Diego CA, US
Assignee:
The Burnham Institute - La Jolla CA
International Classification:
C12P 21/02
C12P 13/04
C12P 13/22
C12P 13/10
US Classification:
435 712, 435 701, 435 691, 435106, 435108, 435114
Abstract:
Methods of detecting interactions of a putative ligand with a selectively labeled target molecule, methods of screening for compounds which bind to a selectively labeled target molecule, methods for calculating the dissociation constant of a ligand that binds to a selectively labeled target molecule, and methods to determine the specific amino acids of a target molecule affected by the binding of a ligand, as well as compounds identified by these screening methods, are provided.

Inhibition Of Bid-Induced Cell-Death Using Small Organic Molecules

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US Patent:
7741521, Jun 22, 2010
Filed:
Dec 22, 2006
Appl. No.:
11/645239
Inventors:
John C. Reed - Rancho Santa Fe CA, US
Maurizio Pellecchia - San Diego CA, US
Assignee:
The Burnham Institute - La Jolla CA
International Classification:
C07C 233/05
C07C 233/65
A61K 31/16
US Classification:
564154, 564 84, 564194, 514604, 514616, 514626
Abstract:
Various phenylamine derivatives are described as well as the use of compounds to inhibit BID protein for controlling apoptotic cascade.

Methods And Compounds Useful To Induce Apoptosis In Cancer Cells

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US Patent:
7812058, Oct 12, 2010
Filed:
Jun 25, 2004
Appl. No.:
10/877781
Inventors:
John C. Reed - Rancho Sante Fe CA, US
Maurizio Pellecchia - San Diego CA, US
Assignee:
The Burnham Institute - La Jolla CA
International Classification:
A01N 29/00
A01N 43/00
A61K 31/655
US Classification:
514743, 514151, 514183
Abstract:
The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.
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Maurizio Pellecchia from San Diego, CA, age ~56 Get Report