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Mauricio R Alvira

from Pittsburgh, PA
Age ~57
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Also known as:
Mauricio Rafael Alvira, Auricio R Alvira
Phone and address:
630 Clyde St, Pittsburgh, PA 15213
(412) 688-0354
Related to:
Alvira Andres, 57Andres A Alvira, 56Victor M Alvira, 59
Connected to:
Jorge Alvira, 59Jossie Alvira, 67Lilliana Alvira, 37Roberto Alvira, 67Vanessa Alvira, 36Wanda V Alvira, 60Brenda Y Alvirde, 29Saul Alvirde, 69Lori E Alvirez, 42Amada Alvis, 39

Mauricio Alvira Phones & Addresses

  • 630 Clyde St, Pittsburgh, PA 15213 (412) 688-0354
  • 4417 Pine, Philadelphia, PA 19104 (215) 382-1451
  • 3928 Spruce St, Philadelphia, PA 19104
  • Wexford, PA
  • State College, PA
  • 4417 Pine St APT 203, Philadelphia, PA 19104 (267) 625-6416

Work

Position: Farming-Forestry Occupation

Skills

Cell Culture

Industries

Biotechnology

Resumes

Resumes

Mauricio Alvira Photo 1

Mauricio Alvira

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Location:
Philadelphia, PA
Industry:
Biotechnology
Skills:
Cell Culture

Publications

Us Patents

Method For Direct Rescue And Amplification Of Integrated Viruses From Cellular Dna Of Tissues

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US Patent:
7235393, Jun 26, 2007
Filed:
Apr 22, 2003
Appl. No.:
10/420284
Inventors:
Guangping Gao - Rosemont PA, US
James M. Wilson - Gladwyne PA, US
Mauricio R. Alvira - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 15/864
C12N 5/10
C12N 7/01
C12N 7/02
C12N 7/08
A61K 48/00
US Classification:
435239, 4353201, 435325, 435366, 435369, 435183, 4352351, 435 5, 435 6, 435237
Abstract:
A method for isolating AAV viruses from cellular DNA of non-human primate (NHP) tissues by transfecting the DNA of NHP into 293 cells, rescuing the virus and amplifying it through serial passages in the presence of adenovirus helper functions is provided. Also provided are kits useful for performing this method.

Adeno-Associated Virus (Aav) Serotype 8 Sequences, Vectors Containing Same, And Uses Therefor

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US Patent:
7282199, Oct 16, 2007
Filed:
Apr 25, 2003
Appl. No.:
10/423704
Inventors:
Guangping Gao - Rosemont PA, US
James M. Wilson - Gladwyne PA, US
Mauricio R. Alvira - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 15/864
C12N 15/35
C12N 15/63
C12N 15/64
C12N 7/01
C12P 21/00
C07K 14/015
C12Q 1/70
C12Q 1/68
US Classification:
424 932, 424 931, 424 936, 4353201, 4352351, 435 691, 435 696, 435325, 435455, 435456, 530350, 530324, 530325, 530326, 530327, 530328
Abstract:
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes, including Factor VIII, is also provided.

Adeno-Associated Virus (Aav) Serotype 8 Sequences, Vectors Containing The Same, And Uses Therefor

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US Patent:
7790449, Sep 7, 2010
Filed:
Sep 6, 2007
Appl. No.:
11/899500
Inventors:
Guangping Gao - Rosemont PA, US
James M. Wilson - Gladwyne PA, US
Mauricio R. Alvira - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 15/63
C12N 15/85
US Classification:
4353201, 435325, 435455
Abstract:
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes, including Factor VIII, is also provided.

Adeno-Associated Virus (Aav) Clades, Sequences, Vectors Containing Same, And Uses Therefor

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US Patent:
7906111, Mar 15, 2011
Filed:
Sep 30, 2004
Appl. No.:
10/573600
Inventors:
James M. Wilson - Gladwyne PA, US
Guangping Gao - Westborough MA, US
Mauricio R. Alvira - Philadelphia PA, US
Luc H. Vandenberghe - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 15/86
C12N 5/10
C12N 15/37
C12N 15/11
C12N 7/01
US Classification:
424 932, 435456, 435325, 4241991, 4242331
Abstract:
Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.

Adeno-Associated Virus (Aav) Serotype 8 Sequences, Vectors Containing Same, And Uses Therefor

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US Patent:
8318480, Nov 27, 2012
Filed:
Oct 31, 2007
Appl. No.:
11/981191
Inventors:
Guangping Gao - Westborough MA, US
James M. Wilson - Glen Mills PA, US
Mauricio R. Alvira - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N 15/63
C12N 15/85
US Classification:
4353201, 435325, 435455
Abstract:
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles.

Method For Detecting Adeno-Associated Virus

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US Patent:
8524446, Sep 3, 2013
Filed:
Dec 8, 2010
Appl. No.:
12/962793
Inventors:
Guangping Gao - West Borough MA, US
James M Wilson - Glen Mills PA, US
Mauricio R. Alvira - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12Q 1/70
C12Q 1/68
C07H 21/04
US Classification:
435 5, 435 612, 536 2372, 536 2433
Abstract:
A method for detecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided, which sample contains DNA and proviral AAV. The method involves subjecting the sample containing DNA to amplification via polymerase chain reaction (PCR) using a first set of primers which specifically amplify a first AAV region. The first AAV region is characterized by having at least 250 nucleotides of AAV capsid nucleic acid sequence, a variable sequence flanked by a sequence of at least 18 nucleotides at the 5′ end of the first AAV region and a sequence of at least 18 nucleotides at the 3′ end of the first AAV region. Each of the 5′ and 3′ at least 18 nucleotides is the same over at least 9 consecutive nucleotides relative to corresponding sequences in an alignment of at least two AAV serotypes. Each of the sets of primers consist of a 5′ primer and a 3′ primer. The method is further useful for identifying AAV sequences in the sample by the presence of amplified proviral AAV sequences.

Compositions And Methods For Production Of Recombinant Viruses, And Uses Therefor

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US Patent:
20030092161, May 15, 2003
Filed:
Sep 19, 2002
Appl. No.:
10/246447
Inventors:
Guangping Gao - Rosemont PA, US
James Wilson - Gladwyne PA, US
Mauricio Alvira - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12N007/00
C12N007/02
C12N015/86
US Classification:
435/235100, 435/239000, 435/456000
Abstract:
An efficient method of producing recombinant virus is described. The method involves transfecting an uncut, circular plasmid containing a recombinant viral genome, a first I-SceI recognition site located 5′ to the viral genome, and a second I-SceI recognition site located 3′ to the adenovirus genome into a host cell. The host cell is then cultured under conditions in which it expresses I-SceI endonuclease. The endonuclease cleaves the I-SceI recognition sites, thereby rescuing the recombinant virus from the plasmid, making it available for packaging into an infectious virus.

Method Of Detecting And/Or Identifying Adeno-Associated Virus (Aav) Sequences And Isolating Novel Sequences Identified Thereby

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US Patent:
20030138772, Jul 24, 2003
Filed:
Nov 12, 2002
Appl. No.:
10/291583
Inventors:
Guangping Gao - Rosemont PA, US
James Wilson - Gladwyne PA, US
Mauricio Alvira - Philadelphia PA, US
International Classification:
C12Q001/68
C12Q001/70
A61K048/00
C12N015/861
C07K014/075
US Classification:
435/005000, 435/006000, 435/456000, 424/093200, 530/350000
Abstract:
A method for detecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided. The invention further provides AAV sequences identified by this method, and vectors constructed using these sequences.
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Mauricio R Alvira from Pittsburgh, PA, age ~57 Get Report