Inventors:
Maria O. Bachynsky - Nutley NJ
Martin H. Infeld - Upper Montclair NJ
Navnit Shah - Clifton NJ
Joel Unowsky - Livingston NJ
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 3174
Abstract:
The absorption of antibiotics given through oral and rectal routes of administration is significantly enhanced by use of the antibiotic in conjunction with a two-component absorption enhancing system made up of an ether of a C. sub. 6 to C. sub. 18 alcohol and a polyoxyethylene glycol together with a second component selected from among polyoxyethylene glycol C. sub. 6 to C. sub. 18 glyceride esters, C. sub. 6 to C. sub. 18 carboxylic acids or salts thereof, and esters of two or more C. sub. 6 to C. sub. 18 carboxylic acids, glycerol and a polyoxyethylene glycol. A carrier and adjuvants are usually included. These compositions can be administered in any convenient oral or rectal dosage form, including tablets, capsules, beadlets and suppositories.