Inventors:
Leroy Coggins - Cary NC
Brian R. Murphy - Glen Echo MD
Dorothy F. Holmes - Groton NY
Lynne J. Anguish - Ithaca NY
James H. Gillespie - Ithaca NY
Assignee:
Cornell Research Foundation, Inc. - Ithaca NY
International Classification:
A61K 2300
A61K 3912
A61K 39145
C12N 700
Abstract:
This invention relates to a method and resulting temperature-sensitive (ts) reassortant virus produced by modifying wild-type equine influenza viruses by utilizing mutagenized human influenza viruses possessing ts lesions and shut off temperatures in the area of 37. degree. -39. degree. C. , preferably 37. degree. -38. degree. C. When utilized as a vaccine for equines, these temperature-sensitive recombinant viruses have the facility to develop only mild symptoms while producing protection against infectious equine influenzal disease.