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Lorin A Thompson

from Cohasset, MA
Age ~54
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Related to:
Florence F Thompson, 95Kasey Thompson, 36Otis L Thompson, 46Chris S Thompsen, 59Alice Wilks, 36Pdiane ThompsonGarret Thompson, 38Margaret Drake, 89
Connected to:
Ace Thompson, 44Adah K Thompson, 67Adam L Thompson, 42Adire C Thompson, 47Adonna A Thompson, 54Adrianne A Thompson, 56Africnetta L Thompson, 44Albria L Thompson, 33Alecia K Thompson, 43Alesia Thompson, 58

Lorin Thompson Phones & Addresses

  • Cohasset, MA
  • Oakland, CA
  • Higganum, CT
  • 1311 Town Colony Dr, Middletown, CT 06457
  • 35 Town Colony Dr, Middletown, CT 06457
  • 402 Foulk Rd, Wilmington, DE 19803
  • 600 Silverside Rd, Wilmington, DE 19809
  • Haddam, CT
  • Augusta, GA

Publications

Us Patents

Lactams As Inhibitors Of A- Protein Production

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US Patent:
6495540, Dec 17, 2002
Filed:
Mar 27, 2001
Appl. No.:
09/817957
Inventors:
Lorin A. Thompson - Wilmington DE
Assignee:
Bristol - Myers Squibb Pharma Company
International Classification:
A61K 3155
US Classification:
51421203, 51421208, 540524, 540525, 540527
Abstract:
This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to -amyloid production such as Alzheimers disease and Downs Syndrome.

Amino Lactam Sulfonamides As Inhibitors Of A Protein Production

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US Patent:
6503901, Jan 7, 2003
Filed:
Oct 7, 2000
Appl. No.:
09/684718
Inventors:
Lorin Andrew Thompson - Wilmington DE
Amy Qi Han - Hockessin DE
Assignee:
Bristol Myers Squibb Pharma Company
International Classification:
C07D41312
US Classification:
514221, 540509
Abstract:
This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to -amyloid production such as Alzheimers disease and Downs Syndrome.

Succinoylamino Carbocycles And Heterocycles As Inhibitors Of A- Protein Production

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US Patent:
6525044, Feb 25, 2003
Filed:
Feb 16, 2001
Appl. No.:
09/788227
Inventors:
Richard E Olson - Wilmington DE
Thomas P Maduskuie - Wilmington DE
Lorin Andrew Thompson - Wilmington DE
Andrew J Tebben - Wallingford PA
Nenghui Wang - Newark DE
Wei Deng - Wilmington DE
Hong Liu - Glen Mills PA
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D48704
US Classification:
514220, 540496
Abstract:
This invention relates to novel carbocycles and heterocycles having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to -amyloid production such as Alzheimers disease and Downs Syndrome.

Use Of Small Molecule Radioligands To Discover Inhibitors Of Amyloid-Beta Peptide Production And For Diagnostic Imaging

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US Patent:
6737038, May 18, 2004
Filed:
May 17, 2000
Appl. No.:
09/573789
Inventors:
Robert Zaczek - Avondale PA
Richard E. Olson - Wilmington DE
Dietmar A. Seiffert - Boothwyn PA
Lorin A. Thompson - Wilmington DE
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 4900
US Classification:
424 92, 424 111, 424 165, 424 181, 424 91
Abstract:
This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying macromolecules involved in APP processing and beta-amyloid production. Furthermore, inhibitors identified by the screening method of the present invention are useful in the treatment of neurological disorders, such as Alzheimers disease, which involve elevated levels of A peptides.

Succinoylamino Lactams As Inhibitors Of A Protein

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US Patent:
6794381, Sep 21, 2004
Filed:
Feb 17, 2000
Appl. No.:
09/506360
Inventors:
Richard E. Olson - Wilmington DE
Thomas P. Maduskuie - Wilmington DE
Lorin Andrew Thompson - Wilmington DE
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D22300
US Classification:
51421203, 51421208, 540524, 540527
Abstract:
This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to -amyloid production such as Alzheimers disease and Downs Syndrome.

Use Of Small Molecule Radioligands To Discover Inhibitors Of Amyloid-Beta Peptide Production And For Diagnostic Imaging

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US Patent:
6878363, Apr 12, 2005
Filed:
May 17, 2001
Appl. No.:
09/859261
Inventors:
Robert Zaczek - Avondale PA, US
Richard E. Olson - Wilmington DE, US
Dietmar A. Seiffert - Boothwyn PA, US
Lorin A. Thompson - Wilmington DE, US
Assignee:
Bristol-Myers Squibb Pharma Company - Princeton NJ
International Classification:
A61K051/00
A61M036/14
US Classification:
424 91, 424 111, 424 165, 424 181, 424 185, 435 23, 435 24
Abstract:
A method of using radiolabelled and/or radiopharmaceutical small molecule inhibitors of beta-amyloid peptide production for the diagnosis of neurological and other disorders involving APP processing and beta-amyloid production. Radiolabelled small molecule inhibitors identified by the methods of the present invention would be useful in the diagnosis of neurological disorders, such as Alzheimer's disease, which involve elevated levels of Aβ peptides.

Hydroxyalkanoylaminolactams And Related Structures As Inhibitors Of Aβ Protein Production

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US Patent:
6960576, Nov 1, 2005
Filed:
Nov 4, 2002
Appl. No.:
10/287117
Inventors:
Richard E. Olson - Wilmington DE, US
Hong Liu - Glen Mills PA, US
Lorin A. Thompson - Wilmington DE, US
Assignee:
Bristol-Myers Squibb Pharma Company - Princeton NJ
International Classification:
C07D243/00
C07D243/24
C07D487/00
C07D223/12
A61K031/55
US Classification:
51421204, 51421207, 51421211, 514218, 514221, 540492, 540509, 540522, 540523, 540527
Abstract:
This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

Benzo-1,4-Diazepin-2-Ones As Inhibitors Of Aβ Protein Production

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US Patent:
6962913, Nov 8, 2005
Filed:
Nov 1, 2002
Appl. No.:
10/285776
Inventors:
Richard E. Olson - Wilmington DE, US
Thomas P. Maduskuie - Wilmington DE, US
Lorin Andrew Thompson - Wilmington DE, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D243/12
A61K031/551
A61P025/28
US Classification:
514221, 540517
Abstract:
This invention relates to novel compounds of the class of succinoyl lactams, such as diazepinee of Formula (Id), or a pharmaceutically acceptable salt thereof, as described above, having drug and bio-affecting properties. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of Alzheimer's disease.
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Lorin A Thompson from Cohasset, MA, age ~54 Get Report