Lara K Mahal

20020160505, Oct 31, 2002

Feb 13, 2002

10/076727

John Groves - Berkeley CA, US
Lara Mahal - New York City NY, US
Carolyn Bertozzi - Berkeley CA, US

C12Q001/00
C12M001/34

435/287100, 435/004000

A method and device for controlled cell adhesion is provided. The device comprises lipid bilayer membranes arranged into discrete areas in a micro-array. They are useful for screening and modulation of living cell adhesion and growth on a solid substrate. The lipid bilayer membranes are doped with various lipids and/or proteins to modulate the adherence of the cells being used in the device.

20110301057, Dec 8, 2011

Jun 3, 2011

13/153046

Daniel C. PROPHETER - El Dorado Hills CA, US
Lara K. MAHAL - South Orange NJ, US

NEW YORK UNIVERSITY - New York NY

C40B 30/04
C40B 50/12
C07K 14/00
C12N 11/00
C40B 40/10

506 9, 435174, 506 18, 530402, 530396, 506 29

The present invention relates to a method of directing in situ oriented immobilization of a protein on a support. This method involves providing a support and contacting the support with a solution. The solution comprises (a) a protein comprising a coupling moiety and (b) a molecule comprising a first group reactive with the support and a second group reactive with the coupling moiety. The molecule binds (i) the support at the first group and (ii) the coupling moiety at the second group, thereby immobilizing and orienting, in situ, the protein on the support. Also described are a protein array and a method of screening compounds for protein interaction.

20120302514, Nov 29, 2012

Oct 30, 2007

11/978778

Carolyn Bertozzi - Albany CA, US
Kevin J. Yarema - Baltimore MD, US
Lara K. Mahal - Austin TX, US

A61K 31/7008
G01N 24/00
C12N 5/071
A61K 31/7004
A61P 35/00

514 23, 514 62, 435375, 435 721

Disclosed are compositions containing glycoconjugates and methods for making the functionalized glycoconjugates, which include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosaccharide into a second saccharide, (iii) conjugates the saccharide to a carrier to form a glycoconjugate, and (iv) extracellularly expresses the glycoconjugate to form an extracellular glycoconjugate comprising a selectively reactive functional group. Methods for forming products at a cell further comprise contacting the functional group of the extracellularly expressed glycoconjugate with an agent that selectively reacts with the functional group to form a product. Subject compositions include cyto-compatible monosaccharides comprising a nitrogen or ether linked functional group selectively reactive at a cell surface and compositions and cells comprising such saccharides.