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Kumkum K Saxena

from Framingham, MA
Age ~59

Kumkum Saxena Phones & Addresses

  • 8 Dotty Ann Dr, Framingham, MA 01701 (508) 405-1262
  • 361 Faneuil St, Brighton, MA 02135 (617) 782-5136
  • Boston, MA

Work

Company: Jakevia consulting Apr 2020 Position: Principal and founder

Education

Degree: Master of Science, Masters School / High School: Delhi University Specialities: Biochemistry

Skills

Biochemistry • Drug Discovery • Protein Chemistry • Biotechnology • Drug Development • Pharmaceutical Industry • Molecular Biology • Protein Purification • Assay Development • Life Sciences • Infectious Diseases • Oncology • Cell Culture • Cell Biology • Lifesciences • Cell • Validation • Biophysical Chemistry • Biophysics • Team Leadership • Mechanism of Action Studies • Target Validation • Research Study Planning • Data Analysis • Scientific Mentoring • Protein Kinases • Analytical Biochemistry • Protein Science

Languages

Hindi

Interests

Science and Technology • Environment • Disaster and Humanitarian Relief

Industries

Biotechnology

Resumes

Resumes

Kumkum Saxena Photo 1

Principal And Founder

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Location:
8 Dotty Ann Dr, Framingham, MA 01701
Industry:
Biotechnology
Work:
Jakevia Consulting
Principal and Founder

Vertex Pharmaceuticals Oct 2011 - Feb 2015
Director, Protein Biochemistry

Vertex Pharmaceuticals Oct 2011 - Feb 2015
Research Fellow Ii and Director -Protein Sciences

Vertex Pharmaceuticals 2006 - 2011
Research Fellow I

Vertex Pharmaceuticals 2004 - 2006
Senior Research Scientist
Education:
Delhi University
Master of Science, Masters, Biochemistry
Delhi University
Bachelors, Bachelor of Science, Chemistry
Boston University School of Medicine
Doctorates, Doctor of Philosophy, Biochemistry
Skills:
Biochemistry
Drug Discovery
Protein Chemistry
Biotechnology
Drug Development
Pharmaceutical Industry
Molecular Biology
Protein Purification
Assay Development
Life Sciences
Infectious Diseases
Oncology
Cell Culture
Cell Biology
Lifesciences
Cell
Validation
Biophysical Chemistry
Biophysics
Team Leadership
Mechanism of Action Studies
Target Validation
Research Study Planning
Data Analysis
Scientific Mentoring
Protein Kinases
Analytical Biochemistry
Protein Science
Interests:
Science and Technology
Environment
Disaster and Humanitarian Relief
Languages:
Hindi

Publications

Us Patents

Crystal Structure Of Human Jak3 Kinase Domain Complex And Binding Pockets Thereof

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US Patent:
7558717, Jul 7, 2009
Filed:
Apr 26, 2005
Appl. No.:
11/114979
Inventors:
Harmon Zuccola - Westwood MA, US
Marc Jacobs - Boston MA, US
Lovorka Swenson - Belmont MA, US
Kumkum Saxena - Framingham MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C12Q 1/00
C12Q 1/48
G01N 33/53
G01N 31/00
C12N 9/00
C12N 9/12
G06G 7/58
US Classification:
703 11, 435 76, 435 771, 435 15, 435183, 435194, 435 4, 702 27
Abstract:
The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.

Crystal Structure Of Human Jak3 Kinase Domain Complex And Binding Pockets Thereof

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US Patent:
8192972, Jun 5, 2012
Filed:
May 26, 2009
Appl. No.:
12/471896
Inventors:
Harmon Zuccola - Westwood MA, US
Marc Jacobs - Boston MA, US
Lovorka Swenson - Belmont MA, US
Kumkum Saxena - Framingham MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C12N 9/00
C12N 9/10
US Classification:
435183, 435194
Abstract:
The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.

Crystal Structure Of Fms-Like Tyrosine Kinase

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US Patent:
20050181975, Aug 18, 2005
Filed:
Sep 15, 2004
Appl. No.:
10/941387
Inventors:
James Griffith - Weston MA, US
James Black - Wenham MA, US
Carlos Faerman - Acton MA, US
Lovorka Swenson - Belmont MA, US
Michael Wynn - Salem MA, US
Fan Lu - Newton MA, US
Judith Lippke - Chestnut Hill MA, US
Kumkum Saxena - Framingham MA, US
International Classification:
A61K038/17
G06F019/00
G01N033/48
G01N033/50
C12N009/12
US Classification:
514002000, 435194000, 702019000
Abstract:
The invention relates to FMS-like tyrosine kinase (FLT3), FLT3 binding pockets or FLT3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to FMS-like tyrosine kinase protein, complexes of FMS-like tyrosine kinase protein, homologues thereof, or FLT-3-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising an FMS-like tyrosine kinase cytoplasmic domain or homologues thereof. The invention also relates to methods of identifying inhibitors of the cytoplasmic domain of FMS-like tyrosine kinase protein.

Crystal Structure Of Human Jak3 Kinase Domain Complex And Binding Pockets Thereof

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US Patent:
20130137125, May 30, 2013
Filed:
May 24, 2012
Appl. No.:
13/479720
Inventors:
Harmon Zuccola - Westwood MA, US
Marc Jacobs - Boston MA, US
Lovorka Swenson - Belmont MA, US
Kumkum Saxena - Framingham MA, US
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED - CAMBRIDGE MA
International Classification:
C12Q 1/48
US Classification:
435 15, 435194
Abstract:
The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexes with AMP-PNP.
Kumkum K Saxena from Framingham, MA, age ~59 Get Report