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Kiranmai Gumireddy

from Newtown Square, PA
Age ~57
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Also known as:
Kiranmai Kiranmai Gumireddy, Kiran Mai
Connected to:
Lourdmareddy B Gumireddy, 51Deborah S Gumkowski, 69Katie A Gumkowski, 42Timothy J Gumkowski, 41Arnold E Gumm, 85Colette M Gumm, 46Darrel C Gumm, 71Elaine F Gumm, 76Eleanor M Gumm, 88Eric M Gumm, 40

Kiranmai Gumireddy Phones & Addresses

  • Newtown Square, PA
  • Bryn Mawr, PA
  • 3900 City Ave, Philadelphia, PA 19131 (215) 477-5281
  • King of Prussia, PA
  • Chicago, IL
  • Providence, RI

Publications

Us Patents

Microrna Modulators And Method For Identifying And Using The Same

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US Patent:
20100196357, Aug 5, 2010
Filed:
Jan 21, 2010
Appl. No.:
12/691448
Inventors:
Qihong Huang - Philadelphia PA, US
Alexander Deiters - Raleigh NC, US
Kiranmai Gumireddy - Philadelphia PA, US
International Classification:
A61K 39/395
C07C 245/08
A61K 31/655
C07D 491/056
A61K 31/4355
A61K 31/566
C07D 413/14
C07D 405/04
C07D 487/04
C07D 487/00
A61P 35/00
A61P 9/00
C07D 487/18
C12Q 1/68
US Classification:
4241301, 534856, 514150, 534851, 546 48, 514280, 514178, 548131, 5482648, 544263, 544236, 540556, 435 6
Abstract:
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.

Microrna Modulators And Method For Identifying And Using The Same

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US Patent:
20100317628, Dec 16, 2010
Filed:
Feb 20, 2009
Appl. No.:
12/918183
Inventors:
Qihong Huang - Philadelphia PA, US
Alexander Deiters - Raleigh NC, US
Kiranmai Gumireddy - Philadelphia PA, US
International Classification:
C12Q 1/68
C09B 29/00
C07D 491/02
C07J 1/00
A61K 31/655
A61K 31/56
A61K 31/4355
A61P 9/00
A61P 35/00
US Classification:
514150, 435 6, 534851, 546 48, 552626, 552625, 514178, 514280, 435375
Abstract:
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.

Microrna Modulators And Method For Identifying And Using The Same

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US Patent:
20120010177, Jan 12, 2012
Filed:
Aug 1, 2011
Appl. No.:
13/195169
Inventors:
Qihong Huang - Philadelphia PA, US
Alexander Deiters - Raleigh NC, US
Kiranmai Gumireddy - Philadelphia PA, US
Assignee:
The Wistar Institute / North Carolina State University - Philadelphia PA
International Classification:
A61K 31/655
C12N 5/02
A61K 31/473
A61P 9/10
C07C 245/08
C07D 221/18
C07C 49/597
A61P 35/00
C12Q 1/68
A61K 31/122
US Classification:
514150, 435 61, 435375, 514284, 514691, 534843, 546 61, 568326
Abstract:
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.

Microrna Modulators And Method For Identifying And Using The Same

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US Patent:
20130023498, Jan 24, 2013
Filed:
Jun 20, 2012
Appl. No.:
13/527932
Inventors:
Qihong Huang - Philadelphia PA, US
Alexander Deiters - Raleigh NC, US
Kiranmai Gumireddy - Philadelphia PA, US
International Classification:
C40B 20/00
A61K 31/655
C12N 5/07
A61P 9/10
A61K 31/435
C07J 1/00
A61K 31/56
A61P 35/00
C07C 245/08
C07D 221/18
US Classification:
514150, 506 2, 534856, 435375, 546 61, 514284, 552642, 514178
Abstract:
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.

Methods And Compositions For Treatment Or Diagnosis Of Cancers Related To Gabra3

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US Patent:
20170198359, Jul 13, 2017
Filed:
Jan 3, 2017
Appl. No.:
15/397506
Inventors:
- Philadelphia PA, US
Kazuko Nishikura - Haddonfield NJ, US
Kiranmai Gumireddy - Newtown Square PA, US
International Classification:
C12Q 1/68
A61K 31/365
A61K 31/5517
G01N 33/574
Abstract:
Compositions and methods for diagnosing and treating breast cancer, including metastatic breast cancer, are provided. In one aspect, a diagnostic composition comprising a reagent which is capable of specifically complexing with, or identifying, GABRA3 is provided. In another aspect, a method of detecting breast cancer in a subject comprising measuring the level of GABRA3 in a biological sample from the subject is provided. In yet another aspect, a method of treating breast cancer is provided, the method comprising: measuring the level of GABRA3 in a biological sample from a subject and treating the subject with a reagent that inhibits the action of GABA when GABRA3 is detected in the sample or when there is an increase in the level of GABRA3 in the sample as compared to a control sample from a healthy subject.

Microrna Modulators And Method For Identifying And Using The Same

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US Patent:
20140255386, Sep 11, 2014
Filed:
Jul 24, 2012
Appl. No.:
14/236456
Inventors:
Qihong Huang - Philadelphia PA, US
Alexander Deiters - Pittsburgh PA, US
Kiranmai Gumireddy - Philadelphia PA, US
Assignee:
NORTH CAROLINA STATE UNIVERSITY - Raleigh NC
THE WISTAR INSTITUTE - Philadelphia PA
International Classification:
C07J 13/00
A61K 31/4245
A61K 45/06
C07D 413/04
C07D 413/12
C07D 405/04
A61K 31/4196
C07D 487/04
A61K 31/519
C07D 249/14
C07D 405/12
C07D 409/12
A61K 31/5025
C07D 471/04
A61K 31/437
C07D 249/12
C07D 403/04
C07D 513/04
A61K 31/433
C07D 251/52
A61K 31/53
C07D 251/48
A61K 31/5377
A61K 31/55
A61K 31/56
C07D 413/14
US Classification:
4241301, 548131, 514364, 5482648, 514384, 544263, 5142621, 5482654, 514383, 544236, 514248, 546119, 514303, 5482642, 544208, 514245, 544113, 5142362, 540579, 51421402, 552530, 514182, 435375
Abstract:
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
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Kiranmai Gumireddy from Newtown Square, PA, age ~57 Get Report