US Patent:
20080051414, Feb 28, 2008
Inventors:
Laurence Hurley - Tucson AZ, US
Daruka Mahadevan - Tucson AZ, US
Haiyong Han - Chandler AZ, US
David Bearss - Cedar Hills UT, US
Hariprasad Vankayalapati - Draper UT, US
Sridevi Bashyam - Bangalore, IN
Ruben Munoz - Chandler AZ, US
Steven Warner - Mesa AZ, US
Kimiko Della Croce - Tucson AZ, US
Daniel Von Hoff - Scottsdale AZ, US
Cory Grand - Salt Lake City UT, US
James Welsh - Oro Valley AZ, US
Assignee:
Arizona Board of Regents on Behalf of The University of Arizona - Tucson AZ
SuperGen,Inc - Dublin CA
International Classification:
A61K 31/496
A61P 35/00
A61P 43/00
C07D 241/04
C07D 401/14
C07D 403/02
C07D 471/04
US Classification:
514252170, 514252120, 514252140, 514252160, 544250000, 544284000, 544295000, 544358000
Abstract:
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R, R, R, X, Z, L, Cycl, Land Cyclare as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.