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Kevin Michael Belyk

from Metuchen, NJ
Age ~55
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Also known as:
Kevin M Belyk
Phone and address:
23 George St, Metuchen, NJ 08840
Related to:
Nancy A Green, 81Nathan M Belyk, 33Ronald BelykDiane BelykMichael E Belyk
Connected to:
Brittney K Belz, 41Christine C Belz, 76Jason D Belz, 48Jeremiah J Belz, 30Kayla C Belz, 34Rick L Belz, 61Samantha T Belz, 30Tonya K Belz, 51Monika Belzak, 38Barbara V Belzer, 78

Kevin Belyk Phones & Addresses

  • 23 George St, Metuchen, NJ 08840
  • 36 School St, Metuchen, NJ 08840
  • 10 Deborah Dr, Somerset, NJ 08873
  • 221 Driscoll Ct, Somerset, NJ 08873
  • Walled Lake, MI
  • Rahway, NJ
  • 268 Alpine Way, Woodbridge, NJ 07095 (732) 750-3348
  • Farmington Hills, MI
  • Oakland, MI
  • Clark, NJ
  • Westland, MI

Work

Company: Merck Nov 2006 Position: Senior scientist in process research; catalysis and automation group

Education

Degree: Bachelors, Bachelor of Science School / High School: University of Michigan, Ann Arbor 1987 to 1992 Specialities: Chemistry

Skills

High Throughput Experimentation • Transition Metal Mediated Cross Coupling... • Asymmetric Phase Transfer Catalysis • Organic Chemistry • Organic Synthesis • Chemistry • Hplc • Chromatography • Synthetic Organic Chemistry • Catalysis • Medicinal Chemistry • Process Optimization • Process Improvement • Asymmetric Catalysis • Heterogeneous Catalysis • Design of Experiments • Asymmetric Synthesis • Homogeneous Catalysis • Organocatalysis • Asymmetric Hydrogenation • Analytical Chemistry • Gmp • Technology Transfer • Drug Discovery • Pharmaceutical Industry • Nmr • Lc Ms • Nuclear Magnetic Resonance • Liquid Chromatography Mass Spectrometry • High Performance Liquid Chromatography • Drug Development • Research • Purification • Drug Design • Research and Development • Mass Spectrometry • Good Laboratory Practice

Industries

Pharmaceuticals

Resumes

Resumes

Kevin Belyk Photo 1

Senior Scientist In Process Research; Catalysis And Automation Group

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Location:
10 Deborah Dr, Somerset, NJ 08873
Industry:
Pharmaceuticals
Work:
Merck
Senior Scientist In Process Research; Catalysis and Automation Group
Merck 2000 - Oct 2006
Senior Scientist In Process Research
Merck 1993 - 1995
Staff Chemist In Process Research
Merck 1992 - 1993
Research Chemist In Process Research
Education:
University of Michigan, Ann Arbor 1987 - 1992
Bachelors, Bachelor of Science, Chemistry Stevenson High School
University of Michigan
Skills:
High Throughput Experimentation
Transition Metal Mediated Cross Coupling Reactions
Asymmetric Phase Transfer Catalysis
Organic Chemistry
Organic Synthesis
Chemistry
Hplc
Chromatography
Synthetic Organic Chemistry
Catalysis
Medicinal Chemistry
Process Optimization
Process Improvement
Asymmetric Catalysis
Heterogeneous Catalysis
Design of Experiments
Asymmetric Synthesis
Homogeneous Catalysis
Organocatalysis
Asymmetric Hydrogenation
Analytical Chemistry
Gmp
Technology Transfer
Drug Discovery
Pharmaceutical Industry
Nmr
Lc Ms
Nuclear Magnetic Resonance
Liquid Chromatography Mass Spectrometry
High Performance Liquid Chromatography
Drug Development
Research
Purification
Drug Design
Research and Development
Mass Spectrometry
Good Laboratory Practice

Publications

Us Patents

Echinocandin Process

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US Patent:
7214768, May 8, 2007
Filed:
Apr 8, 2002
Appl. No.:
10/474893
Inventors:
Kevin M. Belyk - Somerset NJ, US
William R. Leonard - Basking Ridge NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07K 7/00
C07K 7/64
US Classification:
530317, 530318, 530338, 530339, 514 2, 514 9, 514 11, 930270, 930DIG 548, 930DIG 546
Abstract:
This invention relates to an improved process for the minimization of acid-catalyzed reactions of certain echinocandins of the kind disclosed in U. S. Pat. No. 5,378,804. The process involves the use of a boronic acid.

Potassium Salt Of An Hiv Integrase Inhibitor

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US Patent:
7754731, Jul 13, 2010
Filed:
Dec 2, 2005
Appl. No.:
11/293678
Inventors:
Kevin M. Belyk - Somerset NJ, US
Henry G. Morrison - Simi Valley CA, US
Amar J. Mahajan - Piscataway NJ, US
Daniel J. Kumke - Colts Neck NJ, US
Hsien-Hsin Tung - Edison NJ, US
Lawrence Wai - Scotch Plains NJ, US
Vanessa Pruzinsky - Metuchen NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 239/54
A61K 31/515
US Classification:
514269, 544319
Abstract:
Potassium salts of Compound A and methods for their preparation are disclosed, wherein Compound A is of formula:.

Process For The Preparation Of Cgrp Antagonist

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US Patent:
7829699, Nov 9, 2010
Filed:
Apr 6, 2007
Appl. No.:
12/226244
Inventors:
Kevin Belyk - Somerset NJ, US
Nelo Rivera - New Milford NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 471/04
US Classification:
540524
Abstract:
An efficient synthesis for the preparation of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1 -carboxamide, by coupling (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one and 2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride with 1,1′-carbonyldiimidazole (“CDI”) as carbonyl source; and an efficient preparation of the potassium salt of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide.

Process For Preparing N-Alkylated Hydroxypyrimidinone Compounds

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US Patent:
8357798, Jan 22, 2013
Filed:
Jun 4, 2010
Appl. No.:
12/793801
Inventors:
Kevin M. Belyk - Somerset NJ, US
Henry G. Morrison - Simi Valley CA, US
Philip Jones - Rome, IT
Vincenzo Summa - Rome, IT
V. Brett Cooper - Hertfordshire, GB
Amar J. Mahajan - Piscataway NJ, US
Daniel J. Kumke - Colts Neck NJ, US
Hsien-Hsin Tung - Edison NJ, US
Lawrence Wai - Scotch Plains NJ, US
Vanessa Pruzinsky - Metuchen NJ, US
Philip Pye - Guttenberg NJ, US
Remy Angelaud - Union NJ, US
Danny Mancheno - Rego Park NY, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 239/54
US Classification:
544319
Abstract:
Potassium salts of Compound A and methods for their preparation are disclosed, wherein Compound A is of formula:.

Process For Synthesizing 2-Phenyl-1H-Phenanthro[9,10-D]Imidazole Derivative

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US Patent:
20090203922, Aug 13, 2009
Filed:
Nov 17, 2006
Appl. No.:
12/085258
Inventors:
Kevin Michael Belyk - Somerset NJ, US
Benjamin Dorner - Hoboken NJ, US
Frederick Hartner - Branchburg NJ, US
Naoki Yoshikawa - Edison NJ, US
John Limanto - New Brunswick NJ, US
Lushi Tan - Edison NJ, US
Enrique Vazquez - South Plainfield NJ, US
Joseph Payack - Newbury Park CA, US
International Classification:
C07D 235/02
US Classification:
5483017
Abstract:
The present invention describes an efficient and economical process for the preparation of a 2,3-disubstituted 2-phenyl-1h-phenantrho[9,10-d]imidazole derivative that is useful for the large scale production of material for preclinical and clinical use. The process of the present invention represents a convergent approach to generate the 2,3-disubstituted 2-phenyl-1h-phenantrho[9,10-d]imidazole derivative in high overall yield. The compound made by the process of the invention is an inhibitor of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and is therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain.

Cgrp Antagonist Salt

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US Patent:
20100286122, Nov 11, 2010
Filed:
Apr 6, 2007
Appl. No.:
12/086670
Inventors:
Kevin Belyk - Somerset NJ, US
International Classification:
A61K 31/55
C07D 401/14
A61P 25/06
US Classification:
51421208, 540524
Abstract:
An efficient synthesis for the preparation of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin--yl)piperidine-1-carboxamide, by coupling (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one and 2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride with 1,1′-carbonyldiimidazole (“CDI”) as carbonyl source; an efficient preparation of the potassium salt of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin--yl)piperidine-1-carboxamide; efficient syntheses for the preparation of intermediates (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one and 2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride, and the potassium salt of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide including the potassium salt ethanolate and potassium salt hydrate.

Inhibitors Of The Renal Outer Medullary Potassium Channel

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US Patent:
20130217680, Aug 22, 2013
Filed:
Oct 24, 2011
Appl. No.:
13/881574
Inventors:
Alexander Pasternak - Princeton NJ, US
Reynalda K. deJesus - East Brunswick NJ, US
Yuping Zhu - Edison NJ, US
Lihu Yang - Edison NJ, US
Shawn Walsh - Bridgewater NJ, US
Haifeng Tang - Metuchen NJ, US
Dooseop Kim - Seoul, KR
Barbara Pio - Hillsborough NJ, US
Aurash Shahripour - Rahway NJ, US
Kevin Belyk - Metuchen NJ, US
International Classification:
C07D 405/12
C07D 405/14
C07D 471/08
C07D 413/14
C07D 487/08
C07D 413/12
C07D 257/04
US Classification:
514218, 544366, 51425407, 544368, 51425403, 544362, 51425304, 51425405, 544364, 5142531, 540575, 544349, 514249, 546123, 514300
Abstract:
This invention relates to compounds having structural Formula (I); and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir 1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.

Process For Preparing Certain Aza Cyclohexapeptides

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US Patent:
59360623, Aug 10, 1999
Filed:
Jun 12, 1997
Appl. No.:
8/874118
Inventors:
William Leonard - Watchung NJ
Kevin M. Belyk - Metuchen NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07K 700
US Classification:
530317
Abstract:
There is disclosed a novel process for preparing aza cyclohexapeptides of the formula ##STR1## where all variables are defined herein.
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Kevin Michael Belyk from Metuchen, NJ, age ~55 Get Report