Kenneth Allen Solen

60438711, Mar 28, 2000

Mar 3, 1998

9/033919

Kenneth A. Solen - Orem UT
S. Fazal Mohammad - Salt Lake City UT

Brigham Young University - Provo UT

G01N 3348

356 39

An instrument is described for measuring the platelet aggregation in whole blood in response to standard aggregating agents. The instrument is designed to be used in the clinical laboratory to evaluate the functional status of platelets in blood samples drawn from patients suspected of abnormal platelet function, or in a research laboratory to evaluate the effectiveness of platelet agonists or antiplatelet agents. The measurement is based on the scattering of light in the blood sample and does not require separation of erythrocytes from blood and therefore helps minimize the need for handling of blood by the laboratory personnel. The instrument converts the light-scattering data to provide the number and average size of the aggregates per unit volume at various times during the process of aggregation.

53387708, Aug 16, 1994

Apr 12, 1990

7/509063

Suzanne Winters - Salt Lake City UT
Kenneth A. Solen - Orem UT
Clifton G. Sanders - Salt Lake City UT
JD Mortensen - Sandy UT
Gaylord Berry - Salt Lake City UT

Cardiopulmonics, Inc. - Salt Lake City UT

A01N 100
A61M 2500

523112

The present invention is directed to thrombo-resistant coatings for use with gas permeable biomedical devices and implants. The coatings include a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A quantity of at least one bioactive molecule designed to counteract a specific blood-material incompatibility reaction is covalently bonded to the poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is preferably achieved by plasma etching with ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface.

52624510, Nov 16, 1993

Jul 5, 1988

7/215014

Suzanne Winters - Salt Lake City UT
Kenneth A. Solen - Orem UT
Clifton G. Sanders - Salt Lake City UT
J. D. Mortensen - Sandy UT
Gaylord Berry - Salt Lake City UT

Cardiopulmonics, Inc. - Salt Lake City UT

A01N 100

523112

The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas.

53426932, Aug 30, 1994

Mar 22, 1993

8/035426

Suzanne Winters - Salt Lake City UT
Kenneth A. Solen - Orem UT
Clifton G. Sanders - Salt Lake City UT
J. D. Mortensen - Sandy UT
Gaylord Berry - Salt Lake City UT

Cardiopulmonics, Inc. - Salt Lake City UT

B32B 2706
A01N 100

428447

The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas.

51823179, Jan 26, 1993

Jun 17, 1991

7/716843

Suzanne Winters - Salt Lake City UT
Kenneth A. Solen - Orem UT
Clifton G. Sanders - Salt Lake City UT
J. D. Mortensen - Sandy UT
Gaylord Berry - Salt Lake City UT

Cardiopulmonics, Inc. - Salt Lake City UT

A01N 100

523112

The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The method of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas.