Kenneth A Kopher

20020115062, Aug 22, 2002

Dec 8, 2000

09/732838

Robert Fletcher - Phoenixville PA, US
Alvydas Ozinskas - Dayton MD, US
Kenneth Kopher - Baltimore MD, US
John Gill - Phoenix MD, US

C12Q001/70
C12M001/34

435/005000, 435/287200

The present invention provides a method and device for conducting a rapid in vitro enzyme immunoassay test for the direct and qualitative detection of two or more viral antigens from specimens of symptomatic patients. The method for immunoassay of viral antigens is performed on a membrane. Non-immunological capture of viral antigens takes place by absorption onto the membrane. Captured antigen binds to a detection reagent that includes a label conjugated to a specific antibody. The test is a differentiated test such that two or more viral antigens may be distinguished from each other in a single test. The invention also includes a kit for performing an assay in accordance with the method of the present invention, wherein the kit comprises the device of the present invention.

20080014657, Jan 17, 2008

Aug 11, 2006

11/463903

Stephen J. Lovell - Baltimore MD, US
Kenneth A. Kopher - Baltimore MD, US

BECKTON DICKINSON AND COMPANY - Franklin Lakes NJ

G01N 33/558

436514

Devices, kits, and methods are provided for analyzing a sample for the presence or amount of a bacterium in a sample, and for determining whether or not conditions present while practicing the invention allow for accurate test results. Specifically, the invention provides devices, kits, and methods for analyzing a sample for the presence or amount of a bacterial carbohydrate, while using an analog of the bacterial carbohydrate as a control reagent. In certain embodiments, the invention may provide for analyzing a sample for the presence or amount of a Group A (GAS) bacterium, by determining the presence or amount of β-N-Acetyl-D-Glucosamine attached to a poly-rhamnose backbone, a bacterial carbohydrate found in GAS, in the sample, and by using Albumin, Bovine, p-Aminophenyl N-Acetyl B-D Glucosaminide, an analog to β-N-Acetyl-D-Glucosamine as a control reagent.

20160011087, Jan 14, 2016

Apr 4, 2013

14/774392

- Franklin Lakes NJ, US
Kenneth Anthony Kopher - Baltimore MD, US
John D. Mantlo - Westminster MD, US
William Alfred Pope - Owings Mills MD, US
Song Shi - Reisterstown MD, US
Axel A. Yup - Owings Mills MD, US

Becton, Dickinson and Company - Franklin Lakes NJ

G01N 1/30
C12Q 1/04

A process for determining one of the presence, absence, or total of microorganisms (e.g. bacteria) in a sample. According to the process, a biological sample containing complex matrices is obtained. The sample is first combined with a resin to adsorb complex matrices from the sample. The resin is removed from the biological sample. The sample so prepared is then analyzed by flow cytometry.

20150118677, Apr 30, 2015

Apr 4, 2013

14/390596

- Franklin Lakes NJ, US
Yongqiang Zhang - Lutherville MD, US
Kenneth Anthony Kopher - Baltimore MD, US
John D. Mantlo - Westminster MD, US
William Alfred Pope - Owings Mills MD, US
Song Shi - Reisterstown MD, US
Axel A. Yup - Owings Mills MD, US

BECTON, DICKINSON AND COMPANY - Franklin Lakes NJ

C12Q 1/06
G01N 1/30

435 61, 548157

Described herein are methods and reagents for identifying and analyzing at least one microorganism (e.g. bacteria) in a sample and reducing the background signal intensity obtained when analyzing the sample by flow cytometry. The sample is prepared by combining the sample with a background signal-reducing molecule or with a nucleic acid stain covalently linked to a quencher. A portion of the particulate matter in the sample can optionally be removed with a resin prior to staining with a nucleic acid stain.