Kenneth B Guiseley

20070141105, Jun 21, 2007

Oct 6, 2006

11/539580

Thomas Stein - Myersville MD, US
Mark Powers - New Market MD, US
Jonathan Cooper - Walkersville MD, US
Sorin Damian - Frederick MD, US
Pieter Johannes Huiberts - Frederick MD, US
Kenneth Guiseley - Hope ME, US

A61F 2/02
A61K 9/14
C12N 5/02

424423000, 424486000, 435404000

Biocompatible matrices or implants on which one or more specific cell-interactive molecules (“biomolecules”) can be immobilized have been developed. The matrices allow for the independent control of ligand concentration and matrix strength. In one embodiment, the matrix or implant is modified with one or more moieties capable of complexing bioconjugates prepared from one or more biomolecules. Suitable moieties include phenyl boronic acid complexing agents, such as salicylhydroxamic acid, which can complex to one or more biomolecules containing one or more phenyl boronic acid moieties. The biomolecules may be anchored to the matrix via a spacer molecule, which may allow for greater mobility of the biomolecules in aqueous solution. In one embodiment, the matrix is a hydrogel material which has been doubly-derivatized, wherein ligand concentration and matrix strength can be independently controlled. The matrices and implants can be used in vivo and in vitro applications including diagnostics, biosensors, bioprocess engineering, tissue engineering, regeneration and repair, and drug delivery.

40963276, Jun 20, 1978

Jan 5, 1977

5/756815

Kenneth B. Guiseley - Union ME

FMC Corporation - Philadelphia PA

C07H 510

536122

Modified kappa-carrageenan containing hydroxyalkyl groups each having two to three carbon atoms, the degree of substitution of such groups above the corresponding unsubstituted kappa-carrageenan being from 0. 1 to 2. 0 meq. per gram, forms aqueous gels exhibiting decreased syneresis and melting point and increased compliancy as compared with the corresponding unmodified kappa-carrageenan. The modified kappa-carrageenan is useful in food products as well as in latex paint.

49832689, Jan 8, 1991

Aug 3, 1989

7/389141

Francis H. Kirkpatrick - Owls Head ME
Kenneth Guiseley - Union ME
Richard Provonchee - Camden ME
Samuel Nochumson - Randolph NJ

FMC Corporation - Philadelphia PA

C07K 114
C07K 314
B01D 5702

2041828

Purified agarose suitable for rapid electrophoresis, characterized by a sulfate content of less than 0. 2 wt % but greater than zero, a pyruvate content of 0-0. 1 wt %, and a nitrogen content of 0-0. 02 wt %. Gels prepared from the agarose exhibit a gel strength at 1. 0 wt % concentration of at least 1200 g/cm. sup. 2, substantial absence of DNA binding in 0. 07 M or less tris acetate buffer, and an electroendosmosis (EEO) at 1. 0 wt % concentration of 0. 05 or less. Agaroses are purified to provide the low EEO material by dissolving agarose or alkali-modified agar in an aqueous medium buffered at a pH of 6. 0 to 8. 0 and containing no more than 2. 0 nM salt as chloride, and precipitating the agarose by contact with a lower alkanol.

44434863, Apr 17, 1984

Mar 11, 1981

6/242799

Kenneth B. Guiseley - Hope ME

FMC Corporation - Philadelphia PA

C08B 3700
A23G 100
A23C 9154

426584

A stabilizer for milk products comprised of a carrageenan extractive of Eucheuma cottonii seaweed having a water viscosity at 1. 5% concentration and 75. degree. C. of not less than 5 mPa. s and not more than about 20 mPa. s.

39562735, May 11, 1976

Sep 20, 1973

5/398955

Kenneth B. Guiseley - Union ME

Marine Colloids, Inc. - Rockland ME

C08B 3712

260209R

A modified agarose or agar containing alkylated, alkenylated, acylated or hydroxyalkylated agarose in which the alkyl, alkenyl, and acyl groups contain from 1 to 3 carbon atoms and the hydroxyalkyl groups contain from 1 to 4 carbon atoms, which modified product has a gelling temperature at least 1. degree. C. lower than the gelling temperature of the corresponding unmodified agarose or agar. The modified material also has a lowered melting point and a higher clarity than the unmodified. The product is made by alkylation, etc. either in a non-aqueous solvent or in an aqueous alkaline solvent; in the latter case the aldehyde end group of the unmodified material may be first blocked by reduction to the hydroxyl group. The compounds are useful as thickeners, for electrophoresis and for diffusive Interactions.