Inventors:
Alan D. Adams - Cranford NJ, US
A. Brian Jones - Clavering, GB
Joel P. Berger - Hoboken NJ, US
James F. Dropinski - Colts Neck NJ, US
Alexander Elbrecht - Watchung NJ, US
Kun Liu - Edison NJ, US
Karen Lamb MacNaul - Warren NJ, US
Guo-Qiang Shi - Monmouth Junction NJ, US
Derek J. Von Langen - Fanwood NJ, US
Gaochao Zhou - Scotch Plains NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/428
A61K 31/423
US Classification:
514367, 514373, 514 37, 514375, 514379, 548165, 548209, 548221, 548241
Abstract:
A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.