Inventors:
- Oakland CA, US
June X. Zou - Davis CA, US
Junjian Wang - Davis CA, US
Demin Cai - Davis CA, US
Yong Xu - Guangzhou, CN
Xiaoqian Xue - Guangzhou, CN
Yan Zhang - Guangzhou, CN
Assignee:
The Regents of the University of California - Oakland CA
Guangzhou Institutes of Biomedicine and Health - Guangzhou
U.S. Government represented by the Department of Veterans Affairs - Washington DC
International Classification:
A61K 31/167
C07C 205/11
A61K 31/58
A61K 31/277
A61K 31/4166
A61K 45/06
A61P 35/00
A61K 31/138
A61K 31/222
A61K 31/337
Abstract:
The present invention provides compositions, methods, and kits comprising one or more compounds of Formula I, such as XY018, alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g., prostate cancer, such as castration-resistant prostate cancer (CRPC), and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, gastric cancer, lymphoma, and glioma.