Inventors:
Frank S. Gibson - Pennington NJ, US
Joydeep Kant - Cherry Hill NJ, US
Rajendra P. Deshpande - Hillsborough NJ, US
Karen L. TenHuisen - Randolph NJ, US
Jing Liang - Princeton NJ, US
Jun Li - Langhorne PA, US
Susan D. Boettger - Fayetteville NY, US
Edward J. Gublo - Liverpool NY, US
Ulhas P. Dhokte - Jamesville NY, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D 305/14
C07F 7/18
Abstract:
A process is provided for preparing 4-alkyl- or 4-aryl-oxycarbonyl paclitaxel analogs which includes the steps of converting paclitaxel into a C-7 acylprotected paclitaxel employing an electrophilic protecting group, such as benzoyloxycarbonyl, and converting the C-7 protected analog into the 4-alkyloxycarbonyl or 4-aryloxycarbonyl paclitaxel analog. Novel intermediates produced in the process are also provided.