Joseph D Surmatis

40050319, Jan 25, 1977

Feb 19, 1976

5/659459

Joseph Donald Surmatis - West Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07B 300
C01B 1504

252186

Nickel peroxide on a fine, free-flowing carrier, which is formed by treating nickel oxide, deposited on the carrier, with an alkali hypohalite or alkali persulfate in an aqueous alkaline medium, and its use for selectively oxidizing an unsaturated alcohol to the corresponding carbonyl compound.

40038912, Jan 18, 1977

Feb 12, 1975

5/549414

Joseph Donald Surmatis - West Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07D24152

260242

A novel improved procedure is described for the preparation of various metal complexes of 6-methoxy-1-phenazinol 5,10-dioxide by the reaction between 6-methoxy-1-phenazinol 5,10-dioxide and a metal salt or hydroxide in an aqueous suspension or a solution in aqueous mineral acid. Preferred metals disclosed as suitable for use in the process are calcium, strontium, magnesium and iron. Utility of the ferric chloride complex and the calcium complex in the purification of 6-methoxy-1-phenazinol 5,10-dioxide is also disclosed.

39857344, Oct 12, 1976

Feb 13, 1974

5/442297

Joseph Donald Surmatis - West Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07D24146

260242

An improved procedure is described for the preparation of the copper complex of 6-methoxy-1-phenazinol 5,10-dioxide using water as the reaction medium to produce a high yield of free-flowing, crystalline product.

39667340, Jun 29, 1976

Feb 12, 1975

5/549413

Joseph Donald Surmatis - West Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07D24152

260267

A novel improved procedure is described for the preparation of various metal complexes of 6-methoxy-1-phenazinol 5,10-dioxide by the reaction between 6-methoxy-1-phenazinol 5,10-dioxide and a metal salt or hydroxide in an aqueous suspension or a solution in aqueous mineral acid. Preferred metals disclosed as suitable for use in the process are calcium, strontium, magnesium and iron. Utility of the ferric chloride complex and the calcium complex in the purification of 6-methoxy-1-phenazinol 5,10-dioxide is also disclosed.

39741818, Aug 10, 1976

Jan 6, 1975

5/538621

Joseph Donald Surmatis - West Caldwell NJ
Armin Walser - West Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07D31710

2603409

The compound 7,9,9-trimethyl-1,4-dioxoaspiro [4,5] dec-7-en-8-methanol an intermediate in the preparation of Zeaxanthin and Xanthophyll, known coloring agents for foodstuffs.

39418413, Mar 2, 1976

May 17, 1974

5/471089

Joseph Donald Surmatis - West Caldwell NJ
Armin Walser - West Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C 4948

260586R

A method by which rhodoxanthin can be synthesized from 3-ethylenedioxy-. beta. -ionone as well as new and novel intermediates produced in the synthesis. Rhodoxanthin is a well-known coloring agent for foodstuffs, including beverages, pharmaceutical and cosmetic preparations.

39897575, Nov 2, 1976

Apr 29, 1974

5/465202

Joseph Donald Surmatis - West Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C 4500

260598

Cis-isomers of a carotenoid are isomerized to an all-trans-isomer of the carotenoid by heating the cis-isomers in water at above about 50. degree. C.

39324850, Jan 13, 1976

Aug 28, 1974

5/501127

Joseph Donald Surmatis - West Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07C 6700

260468L

Improved preparation of Wittig salts of alpha,beta-unsaturated alcohols by treating the alcohol with a phosphine in a basic medium and in the presence of a salt of a weak organic base with a strong acid. The Wittig salt may be reacted further with an unsaturated aldehyde to form a polyene compound.