Inventors:
James E. Audia - Indianapolis IN
Beverly K. Folmer - Newark DE
Varghese John - San Francisco CA
Lee H. Latimer - Oakland CA
Jeffrey S. Nissen - Indianapolis IN
Jon K. Reel - Carmel IN
Eugene D. Thorsett - Moss Beach CA
Celia A. Whitesitt - Greenwood IN
Assignee:
Athena Neurosciences, Inc. - San Francisco CA
Eli Lilly Company - Indianapolis IN
International Classification:
C07D21538
US Classification:
514311, 514367, 514415, 514423, 514452, 514465, 514467, 514471, 514529, 514533, 514538, 514550, 514567, 546171, 548161, 548496, 548540, 549366, 549439, 549451, 549496, 560 43, 560 45, 560161, 562433, 562457
Abstract:
Disclosed are compounds which inhibit -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimers disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimers disease both prophylactically and therapeutically with such pharmaceutical compositions.