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John P Scovill

from Paoli, PA
Age ~76
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Also known as:
John Paul Scovill
Phone and address:
2100 Quail Ridge Dr, Paoli, PA 19301
(610) 648-9495
Related to:
Mark R Offer, 59Mary Scovill KeltonThomas J Scovill, 74Suzanne M Scovill, 74David M Scovill, 41Cathy A Scovill, 72Mary A ScovillSarah S Scovill, 44
Connected to:
Christina J Scoville, 35Darlene H Scoville, 88Hannah L Scoville, 30Harold D Scoville, 83James M Scovill, 59Jan Scoville, 57Larry M Scoville, 69Marie G Scoville, 94Michelle R Scoville, 55Nicholas Scovill, 47

John Scovill Phones & Addresses

  • 2100 Quail Ridge Dr, Paoli, PA 19301 (610) 648-9495
  • 307 Cramer Ave, Walkersville, MD 21793 (301) 898-1420
  • Silver Spring, MD
  • Rockville, MD
  • Troy, MI
  • Reston, VA
  • Chester, PA

Work

Company: Temple university Aug 2006 Position: Assistant professor of chemistry

Education

Degree: Ph.D School / High School: University of Michigan 1975 Specialities: Medicinal Chemistry

Industries

Chemicals

Resumes

Resumes

John Scovill Photo 1

Lecturer

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Location:
Philadelphia, PA
Industry:
Chemicals
Work:
Temple University since Aug 2006
Assistant Professor of Chemistry
Uniformed Services University since Jan 1997
Adjunct Assistant Professor
Johns Hopkins University since Jan 1994
Lecturer
SAIC - Frederick, MD May 2001 - Aug 2005
Senior Scientist
Bucknell University Sep 1999 - Jun 2001
Visiting Assistant Professor
Education:
University of Michigan 1975
Ph.D, Medicinal Chemistry University of Michigan 1970 - 1974
Ph.D., Medicinal Chemistry Central Michigan University 1966 - 1970
BS, Major -Chemistry; Minor - Math Central Michigan University 1970
B.Sc, Chemistry Walter Reed Army Institute of Research

Publications

Us Patents

Indolo[2,1-B] Quinazole-6, 12-Dione Antimalarial Compounds And Methods Of Treating Malaria Therewith

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US Patent:
6531487, Mar 11, 2003
Filed:
May 8, 2001
Appl. No.:
09/850996
Inventors:
Kevin K. Pitzer - Pasadena MD
John P. Scovill - Walkersville MD
Dennis E. Kyle - Gaithersburg MD
Lucia Gerena - Silver Spring MD
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
A61K 3147
US Classification:
514308, 514152, 514895
Abstract:
Compounds, compositions and methods are provided for treating malaria parasites in vitro and in vivo by administering indolo[2,1-b]quinazoline-6,12-dione compounds of Formula I. wherein A, B, C, D, E, F, G and H are independently selected from carbon and nitrogen, or A and B or C and D can be taken together to be nitrogen or sulfur, with the proviso that not more than three of A, B, C, D, E, F, G and H are other than carbon; wherein R through R are independently selected from the group consisting of, but not limited to, the halogens (F, Cl, Br, and I), alkyl groups, trifluoromethyl groups, methoxyl groups, the carboxy methyl or carboxy ethyl group (COOCH or COOCH CH ), nitro, aryl, heteroaryl, cyano, amino, dialkylaminoalkyl, 1-(4-alkylpiperazinyl), and the pharmaceutically acceptable salts thereof; and wherein X is independently selected from the group consisting of any atom especially oxygen, or any side chain necessary to make the indolo[2,1-b]quinazoline-6,12-dione compound a âprodrugâ as the term is understood by one of ordinary skill in the art of medicinal chemistry. In other words, a side chain having a structure where a carbon-nitrogen double bond bears substituents that make the prodrug more water soluble and bioavailable.

Indolo[2,1-B] Quinazole-6,12-Dione Antimalarial Compounds And Methods Of Treating Malaria Therewith

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US Patent:
8012987, Sep 6, 2011
Filed:
Feb 28, 2006
Appl. No.:
11/364425
Inventors:
Kevin K. Pitzer - Pasadena MD, US
John P. Scovill - Walkersville MD, US
Dennis E. Kyle - Gaithersburg MD, US
Lucia Gerena - Silver Spring MD, US
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
C07D 471/04
C07D 471/22
C07D 487/04
US Classification:
514257
Abstract:
Compounds, compositions and methods are provided for treating malaria parasites in vitro and in vivo by administering indolo [2,1-b]quinazoline-6,12-dione compounds of Formula I.

Indolo[2,1-B] Quinazole-6,12-Dione Antimalarial Compounds And Methods Of Treating Malaria Therewith

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US Patent:
20030191138, Oct 9, 2003
Filed:
Mar 10, 2003
Appl. No.:
10/384979
Inventors:
Kevin Pitzer - Pasadena MD, US
John Scovill - Walkersville MD, US
Dennis Kyle - Gaithersburg MD, US
Lucia Gerena - Silver Spring MD, US
International Classification:
A61K031/519
C07D487/14
US Classification:
514/257000, 544/247000, 514/252160
Abstract:
Compounds, compositions and methods are provided for treating malaria parasites in vitro and in vivo by administering indolo[2,1-b]quinazoline-6,12-dione compounds of Formula I. wherein A, B, C, D, E, F, G and H are independently selected from carbon and nitrogen, or A and B or C and D can be taken together to be nitrogen or sulfur, with the proviso that not more than three of A, B, C, D, E, F, G and H are other than carbon; wherein Rthrough Rare independently selected from the group consisting of, but not limited to, the halogens (F, Cl, Br, and I), alkyl groups, trifluoromethyl groups, methoxyl groups, the carboxy methyl or carboxy ethyl group (COOCHor COOCHCH), nitro, aryl, heteroaryl, cyano, amino, dialkylaminoalkyl, 1-(4-alkylpiperazinyl), and the pharmaceutically acceptable salts thereof; and wherein X is independently selected from the group consisting of any atom especially oxygen, or any side chain necessary to make the indolo[2,1-b]quinazoline-6,12-dione compound a “prodrug” as the term is understood by one of ordinary skill in the art of medicinal chemistry. In other words, a side chain having a structure where a carbon-nitrogen double bond bears substituents that make the prodrug more water soluble and bioavailable.

Indolo[2,1-B] Quinazole-6,12-Dione Antimalarial Compounds And Methods Of Treating Malaria Therewith

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US Patent:
62847724, Sep 4, 2001
Filed:
Sep 28, 1999
Appl. No.:
9/407196
Inventors:
Kevin K. Pitzer - Pasadena MD
John P. Scovill - Walkersville MD
Dennis E. Kyle - Gaithersburg MD
Lucia Gerena - Silver Spring MD
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
A61K 3147
US Classification:
514308
Abstract:
Compounds, compositions and methods are provided for treating malaria parasites in vitro and in vivo by administering indolo[2,1-b]quinazoline-6,12-dione compounds of Formula I. ##STR1## wherein A, B, C, D, E, F, G and H are independently selected from carbon and nitrogen, or A and B or C and D can be taken together to be nitrogen or sulfur, with the proviso that not more than three of A, B, C, D, E, F, G and 14 are other than carbon; wherein R. sub. 1 through R. sub. 8 are independently selected from the group consisting of, but not limited to, the halogens (F, Cl, Br, and I), alkyl groups, trifluoromethyl groups, methoxyl groups, the carboxy methyl or carboxy ethyl group (COOCH. sub. 3 or COOCH. sub. 2 CH. sub. 3), nitro, aryl, heteroaryl, cyano, amino, dialkylaminoalkyl, 1-(4-alkylpiperazinyl), and the pharmaceutically acceptable salts thereof; and wherein X is independently selected from the group consisting of any atom especially oxygen, or any side chain necessary to make the indolo[2,1 -b]quinazoline-6,12-dione compound a "prodrug" as the term is understood by one of ordinary skill in the art of medicinal chemistry.

2-Acetyl-And 2-Propionylpyridine Thiosemicarbazones

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US Patent:
47390697, Apr 19, 1988
Filed:
Dec 7, 1984
Appl. No.:
6/679183
Inventors:
Daniel L. Klayman - Chevy Chase MD
John P. Scovill - Rockville MD
Joseph F. Bartosevich - Silver Spring MD
Carl J. Mason - Silver Spring MD
T. Scott Griffin - Orange CA
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
C07D21353
US Classification:
546331
Abstract:
This invention relates to various 2-acetyl- and 2-propionylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

2-Acetyl-And 2-Propionylpyridine Thiosemicarbazones

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US Patent:
43177760, Mar 2, 1982
Filed:
Jan 4, 1979
Appl. No.:
6/004247
Inventors:
Daniel L. Klayman - Chevy Chase MD
John P. Scovill - Rockville MD
Joseph F. Bartosevich - Silver Spring MD
Carl J. Mason - Silver Spring MD
T. Scott Griffin - Orange CA
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
C07D21124
A61N 3144
US Classification:
2602444
Abstract:
This invention relates to various 2-acetyl- and 2-propionylpyridine thioscarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

Method For Treating Gonorrhea Infections With 2-Acetyl- And 2-Propionylpyridine Thiosemicarbazones

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US Patent:
44016700, Aug 30, 1983
Filed:
Oct 14, 1981
Appl. No.:
6/311370
Inventors:
Daniel L. Klayman - Chevy Chase MD
John P. Scovill - Rockville MD
Joseph F. Bartosevich - Silver Spring MD
Carl J. Mason - Silver Spring MD
T. Scott Griffin - Orange CA
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
A61K 2700
A61K 31495
A61K 31435
A61K 31445
US Classification:
424250
Abstract:
This invention relates to various 2-acetyl- and 2-propionylpyridine thioscarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

Medicinal 2-Acetyl- And 2-Propionylpyridine Thiosemicarbazones And Preparation Thereof

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US Patent:
44939302, Jan 15, 1985
Filed:
Oct 14, 1981
Appl. No.:
6/311371
Inventors:
Daniel L. Klayman - Chevy Chase MD
John P. Scovill - Rockville MD
Joseph F. Bartosevich - Silver Spring MD
Carl J. Mason - Silver Spring MD
T. Scott Griffin - Orange CA
Assignee:
The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:
C07D40112
A61K 31495
US Classification:
544360
Abstract:
This invention relates to various 2-acetyl- and 2-propionylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.
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John P Scovill from Paoli, PA, age ~76 Get Report