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John J Perumattam

from Los Altos, CA
Age ~75
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Also known as:
Annamma J Perumattam, Annie J Perumattam, John N, John Annamma
Phone and address:
30 Chester Cir, Los Altos, CA 94022
(650) 917-9621
Connected to:
Nikhil Perumbeti, 41Robert M Perunko, 82Maria L Perusich, 50Stephen A Perusich, 66Austin T Peruski, 36Denise Peruski, 73Gerard W Peruski, 63Michael E Peruski, 49Michelle R Peruski, 55Nicholas R Peruzzaro, 42

John Perumattam Phones & Addresses

  • 30 Chester Cir, Los Altos Hills, CA 94022 (650) 917-9621
  • Los Altos, CA
  • Sunnyvale, CA
  • Brighton, MA
  • Baltimore, MD
  • Forest Hills, NY
  • Hydesville, CA
  • 30 Chester Cir, Los Altos, CA 94022 (650) 793-3216

Work

Company: Johnson & johnson Jan 2000 to Oct 2006 Position: Senior scientist ii

Education

Degree: Doctorates, Doctor of Philosophy School / High School: The City University of New York 1980 to 1985 Specialities: Organic Chemistry

Skills

Medicinal Chemistry • Drug Discovery • Drug Design • Organic Synthesis • Drug Development • Hplc • Organic Chemistry

Languages

English

Industries

Pharmaceuticals

Resumes

Resumes

John Perumattam Photo 1

Senior Scientist

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Location:
30 Chester Cir, Los Altos, CA 94022
Industry:
Pharmaceuticals
Work:
Johnson & Johnson Jan 2000 - Oct 2006
Senior Scientist Ii
Scios 1987 - 2000
Senior Scientist
Seres Laboratories 1987 - 2000
Senior Scientist
Education:
The City University of New York 1980 - 1985
Doctorates, Doctor of Philosophy, Organic Chemistry
Skills:
Medicinal Chemistry
Drug Discovery
Drug Design
Organic Synthesis
Drug Development
Hplc
Organic Chemistry
Languages:
English

Publications

Us Patents

Compounds And Methods To Treat Cardiac Failure And Other Disorders

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US Patent:
6340685, Jan 22, 2002
Filed:
Mar 24, 1999
Appl. No.:
09/275176
Inventors:
Babu J. Mavunkel - Sunnyvale CA
John A. Lewicki - Los Gatos CA
David Y. Liu - Palo Alto CA
George F. Schreiner - Los Altos Hills CA
John J. Perumattam - Los Altos CA
Assignee:
Scios, Inc. - Sunnyvale CA
International Classification:
A61K 31496
US Classification:
514253, 544367, 544370, 544373
Abstract:
A compound of the formula: and the pharmaceutically acceptable salts thereof, wherein each of Z and Z is independently CR or N; where each R is independently H or is alkyl (1-6C) optionally including one or more heteroatoms selected from O, S and N and optionally substituted by one or more of halo, OR, SR, NR , RCO, COOR, CONR , OOCR, or NROCR where R is H or alkyl (1-6C), or by CN or O, or by an aliphatic or aromatic 5 or 6 membered ring optionally containing 1-2 N heteroatoms; or two R taken together form a bridge optionally containing a heteroatom; R is âwherein X is CO or an isostere thereof; m is 0 or 1; Y is optionally substituted alkyl, optionally substituted aryl, or optionally substituted arylalkyl or two 6 taken together may form an alkyene (2-3C) bridge; n is 0 or 2; Z is CH or N; X is CH, CH or an isostere thereof; and Ar consists of one or two phenyl moieties directly coupled to X optionally substituted by halo, nitro, alkyl (1-6C), alkenyl (1-6C), CN or CF , or by RCO, COOR, CONR , NR , OR, SR, OOCR or NROCR wherein R is H or alkyl (1-6C) or by phenyl, itself optionally substituted by the foregoing substituents; R is H, or alkyl (1-6C) optionally including one heteroatom which is O, S or N, and optionally substituted by one or more of halo, OR, SR, NR , RCO, COOR, CONR , OOCR, or NROCR where R is H or alkyl (1-6C), or by CN or O, or by an aliphatic or aromatic 5 or 6 membered ring optionally containing 1-2 N heteroatoms; R is H, halo, NO , alkyl (1-6C), alkenyl (1-6C), CN, OR, SR, NR , RCO, COOR, CONR , OOCR, or NROCR where R is H or alkyl (1-6C).

Quinazoline Derivatives As Medicaments

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US Patent:
6476031, Nov 5, 2002
Filed:
Aug 27, 1999
Appl. No.:
09/383825
Inventors:
Sarvajit Chakravarty - Sunnyvale CA
Sundeep Dugar - Bridgewater NJ
John J. Perumattam - Los Altos CA
George F. Schreiner - Los Altos Hills CA
David Y. Liu - Palo Alto CA
John A. Lewicki - Los Gatos CA
Assignee:
Scios, Inc. - Sunnyvale CA
International Classification:
C07D23994
US Classification:
514249, 544293, 544258, 544279, 514259, 514258, 51425217
Abstract:
The invention is directed to methods to inhibit TGF- and/or p38- kinase using compounds of the formula or the pharmaceutically acceptable salts thereof wherein R is a noninterfering substituent; each Z is CR or N, wherein no more than two Z positions in ring A are N, and wherein two adjacent Z positions in ring A cannot be N; each R is independently a noninterfering substituent; L is a linker; n is 0 or 1; and Arâ is the residue of a cyclic aliphatic, cyclic heteroaliphatic, aromatic or heteroaromatic moiety optionally substituted with 1-3 noninterfering substituents.

Compounds And Methods To Treat Cardiac Failure And Other Disorders

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US Patent:
6589954, Jul 8, 2003
Filed:
May 21, 1999
Appl. No.:
09/316761
Inventors:
Babu J. Mavunkel - Sunnyvale CA
David Y. Liu - Palo Alto CA
George F. Schreiner - Los Altos Hills CA
John A. Lewicki - Los Gatos CA
John J. Perumattam - Los Altos CA
Assignee:
Scios, Inc. - Sunnyvale CA
International Classification:
A61K 31495
US Classification:
514253, 544367, 544373
Abstract:
Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful in treating cardiac conditions associated with heart failure and in treating conditions characterized by proinflammation.

Inhibitors Of P38 Kinase

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US Patent:
6821966, Nov 23, 2004
Filed:
Nov 20, 2001
Appl. No.:
09/990187
Inventors:
Sundeep Dugar - San Jose CA
John Perumattam - Los Altos CA
Gregory Luedtke - Sunnyvale CA
Xuefei Tan - Sunnyvale CA
Qing Lu - Foster City CA
Assignee:
Scios, Inc. - Freemont CA
International Classification:
C07D40306
US Classification:
51421705, 5142315, 51425409, 51425211, 51425404, 544121, 544373, 544357, 544364, 544369, 540598, 546187, 546201
Abstract:
The invention is directed to methods to inhibit p38- kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein B is âW âCOX Y wherein Y is COR or an isostere thereof and R is hydrogen or a noninterfering substituent, each of W and X is a spacer of 2-6 , and each of i and j is independently 0 or 1; each R is independently a noninterfering substituent, where n is 0-3; Z is NR or O; wherein R is H or a noninterfering substituent; one Z is CA or CR A and the other is CR , CR , NR or N wherein each R , R and R is independently hydrogen or noninterfering substituent; wherein A is: such that Z is CR or N wherein R is hydrogen or a noninterfering substituent; each of l and k is an integer from 0-2 wherein the sum of l and k is 0-3; Ar is an aryl group substituted with 0-5 noninterfering substituents, wherein two noninterfering substituents can form a fused ring; each R is independently a noninterfering substituent where m is 0-4; each of L and L is a linker; and the distance between the atom of Ar linked to L and the center of the ring is 4. 5-24.

Indole-Type Derivatives As Inhibitors Of P38 Kinase

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US Patent:
6864260, Mar 8, 2005
Filed:
May 28, 2002
Appl. No.:
10/157048
Inventors:
Babu J. Mavunkel - Sunnyvale CA, US
Sarvajit Chakravarty - Sunnyvale CA, US
John J. Perumattam - Los Altos CA, US
Sundeep Dugar - San Jose CA, US
Qing Lu - Foster City CA, US
Xi Liang - Mountain View CA, US
Assignee:
Scios, Inc. - Fremont CA
International Classification:
A61K031/495
C07D403/06
US Classification:
514253, 544367, 544370, 544373
Abstract:
The invention is directed to methods to inhibit p-α kinase using compounds which contain a phenyl group linked through a piperazine ring to a substituted indole.

Indole-Type Derivatives As Inhibitors Of P38 Kinase

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US Patent:
6867209, Mar 15, 2005
Filed:
May 19, 2000
Appl. No.:
09/575060
Inventors:
Babu J. Mavunkel - Sunnyvale CA, US
Sarvajit Chakravarty - Sunnyvale CA, US
John J. Perumattam - Los Altos CA, US
Sundeep Dugar - San Jose CA, US
Qing Lu - Foster City CA, US
Xi Liang - Mountain View CA, US
Assignee:
Scios, Inc. - Freemont CA
International Classification:
A61K031/495
C07D241/04
US Classification:
514253, 514183, 5142328, 5142352, 5142358, 540481, 544121, 544142, 544363, 544396
Abstract:
The invention is directed to methods to inhibit p38-α kinase using compounds of the formula.

Indole-Type Inhibitors Of P38 Kinase

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US Patent:
6890938, May 10, 2005
Filed:
Nov 20, 2001
Appl. No.:
09/989991
Inventors:
Gregory Luedtke - Sunnyvale CA, US
Richland Tester - San Jose CA, US
Sundeep Dugar - San Jose CA, US
Qing Lu - Foster City CA, US
John Perumattam - Los Altos CA, US
Xuefei Tan - Sunnyvale CA, US
Assignee:
Scios, Inc. - Fremont CA
International Classification:
A61K031/445
C07D401/06
US Classification:
514323, 514409, 546201, 548409
Abstract:
Compound with an indole linked through an aliphatic ring system to an aromatic moiety are useful in treating conditions associated with enhanced P38α kinase activity.

Quinazoline Derivatives As Medicaments

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US Patent:
6903096, Jun 7, 2005
Filed:
Oct 5, 2001
Appl. No.:
09/972582
Inventors:
Sarvajit Chakravarty - Sunnyvale CA, US
Sundeep Dugar - Bridgewater NJ, US
John J. Perumattam - Los Altos CA, US
George F. Schreiner - Los Altos Hills CA, US
David Y. Liu - Palo Alto CA, US
John A. Lewicki - Los Gatos CA, US
Assignee:
Scios, Inc. - Fremont CA
International Classification:
C07D239/94
C07D471/04
A61K031/517
A61K031/519
US Classification:
5142345, 51426621, 51426411, 5142621, 51425217, 5142662
Abstract:
The invention is directed to methods to inhibit TGF-β and/or p38-α kinase using compounds of the formula or the pharmaceutically acceptable salts thereof.

Wikipedia

Missiary Society of St Thomas

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Kurian Vanchipurackal and John Perumattam were the members of that committee. A second meeting of the priests was convened on 3 March 1964. Its main purpose was to discuss the draft ...
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John J Perumattam from Los Altos, CA, age ~75 Get Report