US Patent:
20130131070, May 23, 2013
Inventors:
John K. Buolamwini - Cordova TN, US
International Classification:
C07D 471/04
C07D 491/048
C07D 495/04
US Classification:
514249, 546 86, 514292, 435375, 544353, 546 85, 546 80, 514291, 546 89
Abstract:
Provided are 1-aryl or 1-heteroaryl substituted beta-carboline compounds or indole analogs thereof having the structure:where X is NH, N—C-Calkyl, S, or O; Ris 1-naphthyl or 1-dihydroacenaphthenyl, each optionally substituted with a halogen; and R, R, R, R, R, and Rare independently H H, OH, halogen, CN, C-Calkyl, C-Calkoxy, C-Chaloalkoxy, —C(O)OC-Cester, —C-C—SO—NH—C-Csulfonamide, or phenyl with the proviso that X is NH, Ris 1-naphthyl or 1-naphthyl substituted with a halogen and one of R, R, or Ris C-Calkoxy, then R, R, R, R, R, and Rare independently H, OH, halogen, CN, C-Chaloalkoxy, —C(O)OC-Cester, —C-C—SO—NH—C-Csulfonamide, or phenyl such that at least two of R, R, R, R, R, and Rare other than H. Also provided are methods for inhibiting proliferation of cells associated with a cell proliferative disease by contacting the cell with the compounds provided herein.