Inventors:
Matthew Burger - Albany CA, US
Jiong Lan - Moraga CA, US
Mika Lindvall - Oakland CA, US
Gisele Nishiguchi - Albany CA, US
Michelle Tetalman - Oakland CA, US
International Classification:
A61K 31/4545
C07D 213/75
C07D 417/12
C07D 413/14
US Classification:
5462707, 546193, 514318, 514342
Abstract:
The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pim kinase activity and/or the prophylaxis or treatment of cancer.