US Patent:
20050239054, Oct 27, 2005
Inventors:
Murty Arimilli - Oakridge NC, US
Mark Becker - Redwood City CA, US
Gabriel Birkus - Foster City CA, US
Clifford Bryant - Millbrae CA, US
James Chen - San Ramon CA, US
Xiaowu Chen - San Mateo CA, US
Tomas Cihlar - Foster City CA, US
Azar Dastgah - San Mateo CA, US
Eugene Eisenberg - San Carlos CA, US
Maria Fardis - San Carlos CA, US
Marcos Hatada - Fremont CA, US
Gong-Xin He - Fremont CA, US
Haolun Jin - Foster City CA, US
Choung Kim - San Carlos CA, US
William Lee - Los Altos CA, US
Christopher Lee - San Francisco CA, US
Kuei-Ying Lin - Fremont CA, US
Hongtao Liu - Cupertino CA, US
Richard MacKman - Millbrae CA, US
Martin McDermott - Redwood City CA, US
Michael Mitchell - Foster City CA, US
Peter Nelson - Los Altos CA, US
Hyung-Jung Pyun - Fremont CA, US
Tanisha Rowe - Modesto CA, US
Mark Sparacino - Morgan Hill CA, US
Sundaramoorthi Swaminathan - Burlingame CA, US
James Tario - San Mateo CA, US
Jianying Wang - Foster City CA, US
Matthew Williams - San Mateo CA, US
Lianhong Xu - San Mateo CA, US
Zheng-Yu Yang - Foster City CA, US
Richard Yu - San Francisco CA, US
Jiancun Zhang - Oakland CA, US
Lijun Zhang - Palo Alto CA, US
International Classification:
C12Q001/70
A61K031/675
A61K031/66
US Classification:
435005000, 514114000, 514080000
Abstract:
Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.