Jian C Lin

6340887, Jan 22, 2002

Sep 21, 1999

09/400228

Kecheng Liu - Solon OH
Jian Lin - Solon OH
Paul M. Margosian - Lakewood OH

Picker International Inc. - Highland Heights OH

G01V 300

324309, 324306

A black blood magnetic resonance angiogram is produced by exciting dipoles ( ) and repeatedly inverting the resonance ( ,. . . ) to produce a series of magnetic resonance echoes ( ,. . . ). Early echoes (e. g. , ( ,. . . , 56 )) are more heavily proton density weighted than later echoes (e. g. , ( )) which are more heavily T2 weighted. The magnetic resonance echoes are received and demodulated ( ) into a series of data lines. The data lines are sorted ( ) between the more heavily proton density weighted data lines and T2 weighted data lines which are reconstructed into a proton density weighted image representation and a T2 weighted image representation. The proton density weighted and T2 weighted image representations are combined ( ) to emphasize the black blood from the T2 weighted images and the static tissue from the proton density weighted image. The combined image is a black blood magnetic resonance angiogram. The production of the angiogram is time efficient and displays enhanced vessel depiction.

6397096, May 28, 2002

Mar 31, 2000

09/540341

Kecheng Liu - Solon OH
Paul M. Margosian - Lakewood OH
Jian Lin - Solon OH

Philips Medical Systems (Cleveland) Inc. - Highland Heights OH

A61B 5055

600419, 382130, 324307, 324309

A black blood magnetic resonance angiogram is produced by exciting dipoles ( ) and repeatedly inverting the resonance ( ,. . . ) to produce a series of magnetic resonance echoes ( ,. . . ). Early echoes (e. g. , ( )) are more heavily proton density weighted than later echoes (e. g. , ( )), which are more heavily T weighted. The magnetic resonance echoes are received and demodulated ( ) into a series of data lines. The data lines are sorted ( ) between the more heavily proton density weighted data lines and T weighted data lines which are reconstructed into a proton density weighted image representation and a T weighted image representation. The proton density weighted and T weighted image representations are combined ( ) to emphasize the black blood from the T weighted images and the static tissue from the proton density weighted image. The combination processor ( ) scales ( ) the PDW and T W images to a common maximum intensity level. The PDW and T W image representations are then combined, e. g.

20130305396, Nov 14, 2013

Sep 28, 2011

13/876232

Luigi Grasso - Bryn Mawr PA, US
Jian Min Lin - Malvern PA, US
Yuhong Zhou - Phoenixville PA, US
Brian E. Tomkowicz - East Norriton PA, US
Nicholas C. Nicolaides - Glen Mills PA, US
Philip M. Sass - Audubon PA, US

A61K 49/00

800 3, 800 18, 435354, 435 723

Provided herein are rodents that express the human endosialin gene. In preferred embodiments, the rodent is a mouse. Preferably, the human endosialin gene is integrated into the native or endogenous endosialin gene locus. More preferably, the host rodent is null for the endogenous endosialin gene product. The human endosialin gene is preferably expressed in a similar development and disease response pattern as that of the native endosialin gene product in parental or wild type rodents. This feature makes these rodents useful for studying the effects of test agents to positively or negatively affect endosialin biology for therapeutic use. Use of human endosialin expressing rodents lacking native endosialin gene product (HUE rodents) is proposed as a strategy for developing agents that can positively or negatively affect the endosialin pathway and also serve as a screening tool to identify those agents that may be useful as human therapies.