Inventors:
Yuan-Ping Pang - Rochester MN, US
Jewn Giew Park - Rochester MN, US
Shaohua Wang - Rochester MN, US
Anuradha Vummenthala - Iowa City IA, US
Rajesh K Mishra - Iowa City IA, US
Jon Davis - Silver Spring MD, US
Charles B. Millard - Frederick MD, US
James J. Schmidt - Mt. Airy MD, US
Assignee:
Mayo Foundation for Medical Education and Research - Rochester MN
U.S. Army Medical Research and Material Command - Washington DC
International Classification:
A01N 43/78
A01N 43/80
A01N 43/76
A01N 43/50
A01N 43/56
A61K 31/425
A61K 31/42
A61K 31/415
C07D 271/00
C07D 285/02
C07D 285/04
C07D 417/00
C07D 513/00
C07D 277/20
C07D 275/02
C07D 263/30
C07D 413/00
C07D 261/06
C07D 257/04
C07D 257/10
C07D 403/00
C07D 487/00
C07D 249/04
C07D 249/08
C07D 233/61
C07D 231/00
C07D 207/00
US Classification:
514365, 514372, 514374, 514378, 514396, 514403, 548125, 548202, 548214, 548235, 548254, 548255, 5482672, 5483355, 5483751, 548566, 548247
Abstract:
This disclosure relates to materials and methods for inhibiting Botulinum neurotoxin, and more particularly to materials and methods for inhibiting the zinc endopeptidase of Botulinum neurotoxin serotypes A, D and/or E (BoNTA, BoNTD and/or BoNTE).