Inventors:
Daniel M. Teller - Columbus OH
Alan R. Davis - Wayne PA
Michael D. Lubeck - Glenmoore PA
Jehan F. Bagli - Princeton NJ
Assignee:
American Home Products Corporation - New York NY
International Classification:
A61K 31505
Abstract:
Antiviral activity against respiratory syncytial virus has been found in some substituted 6-aminopyrimidines having the formula: ##STR1## wherein R. sup. 1 is lower alkyl, preferably methyl or t-butyl, R. sup. 2 is halogen or cyano, and R. sup. 3 is C. sub. 1 -C. sub. 6 alkyl or --(CH. sub. 2). sub. n R. sup. 4 where n is 1 or 2 and R. sup. 4 is phenyl, phenyl substituted by lower alkoxy, lower alkyleneoxy, bromo, or 3,4-methylenedioxy; 3 or 4-pyridinyl, pyridinyl substituted by cyano or bromo, thienyl, or di-(C. sub. 1 -C. sub. 6 alkyl)amino.