US Patent:
20110086338, Apr 14, 2011
Inventors:
Jeeseong Hwang - Gaithersburg MD, US
Rotem Edgar - Potomac MD, US
Michael Mckinstry - Fairmont WV, US
Gary Giulian - Gaithersburg MD, US
Carl Merril - Bethesda MD, US
Sankar Adhya - Gaithersburg MD, US
International Classification:
C12Q 1/70
C12N 7/00
Abstract:
The invention is related to a non-biotinylated bacteriophage that comprises a nucleic acid sequence encoding a biotinylation domain, a complex that comprises a biotinylated bacteriophage and a biotin-specific ligand conjugated bioconjugate, and a method of detecting a bacterial cell in a sample comprising contacting the sample with a non-biotinylated bacteriophage that comprises a nucleic acid sequence encoding a biotinylation domain, wherein the bacteriophage is specific to the bacterial cell.